SCHEMBL7018968

SCHEMBL7018968

[c]1cccc2[nH]c(Cn3ccnc3)nc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 0.43
TBXAS1 P24557 5/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP11B1 P15538 11/20 0.42
CYP11B2 P19099 8/20 0.42
POLB P06746 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
MAPT P10636 1/20 0.42
QPCT Q16769 1/20 0.42
CYP4Z1 Q86W10 1/20 0.42
QPCTL Q9NXS2 1/20 0.42
PON1 P27169 1/20 0.40
CYP17A1 P05093 1/20 0.38
CYP2A6 P11509 1/20 0.38
CYP2B6 P20813 1/20 0.38
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3707917 0.77 PON1 (0.59) CYP19A1TBXAS1MEN1KMT2ASMN1; SMN2
SCHEMBL7969778 0.74 CYP11B1 (0.47) CYP19A1TBXAS1MEN1KMT2ASMN1; SMN2
SCHEMBL7016670 0.73 MEN1 (0.39) CYP19A1TBXAS1MEN1KMT2ACYP11B1
SCHEMBL7019566 0.71 TDP1 (0.40) MEN1KMT2APOLB
SCHEMBL908058 0.71 DDAH1 (0.33) SMN1; SMN2POLB
SCHEMBL7017120 0.71 CACNA1H (0.36) POLB
SCHEMBL7021216 0.71 DDAH1 (0.53) SMN1; SMN2POLBMAPTTSHR
SCHEMBL7020819 0.71 HTT (0.46) CYP3A4
SCHEMBL7014740 0.70 HPGD (0.63) MAPTTSHR
SCHEMBL7024978 0.69 DDAH1 (0.39) KMT2ASMN1; SMN2POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051415-B1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2003-09-24 EP disclosed
US-6495542-B1 SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-12-17 US disclosed
EP-1051415-A1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-11-15 EP disclosed
WO-1999037637-A1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-07-29 WO disclosed