Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 12/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.43 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480487 | 0.80 | PKN1 (0.51) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| SCHEMBL3707917 | 0.78 | PON1 (0.59) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| SCHEMBL6994637 | 0.75 | CHEK1 (0.56) | CHEK1MEN1KMT2APOLBMAPT | |
| SCHEMBL7479170 | 0.74 | MEN1 (0.43) | CYP11B1CYP11B2CHEK1CYP19A1MEN1 | |
| SCHEMBL7483052 | 0.74 | HTT (0.58) | CHEK1MEN1KMT2APOLBMAPT | |
| SCHEMBL7018968 | 0.74 | CYP19A1 (0.43) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| SCHEMBL5736933 | 0.74 | CHEK1 (0.55) | CHEK1MEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL7479734 | 0.73 | HTT (0.61) | CHEK1MEN1KMT2APOLBMAPT | |
| SCHEMBL3938941 | 0.72 | CHEK1 (0.57) | CHEK1MEN1KMT2APOLBMAPT | |
| SCHEMBL8599171 | 0.72 | CHEK1 (0.61) | CHEK1MEN1KMT2ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |