SCHEMBL7019344

SCHEMBL7019344

CC(C)Oc1cc(-n2c(=O)cc(C(F)(F)F)n(N)c2=O)c(F)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPOX P50336 6/20 0.43
MEN1 O00255 1/20 0.39
NR1I2 O75469 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
MAPT P10636 1/20 0.35
CYP2C9 P11712 1/20 0.35
ALOX12 P18054 1/20 0.35
CYP2C19 P33261 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
BCAT1 P54687 5/20 0.33
BCAT2 O15382 4/20 0.33
GAA P10253 1/20 0.33
DHODH Q02127 4/20 0.31
CSNK2A1 P68400 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9049760 0.89 PPOX (0.34) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL9541517 0.88 PPOX (0.44) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL10574106 0.85 PPOX (0.42) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL10577262 0.84 PPOX (0.42) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL10695495 0.83 PPOX (0.41) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL10578354 0.82 PPOX (0.41) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL10573567 0.81 PPOX (0.40) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL10578869 0.81 PPOX (0.40) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL10576117 0.81 PPOX (0.45) PPOXMEN1NR1I2KMT2ATDP1
SCHEMBL9049765 0.81 BCAT1 (0.33) PPOXNR1I2BCAT1BCAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0517181-B1 Amino uracil derivatives, and their production and use SUMITOMO CHEMICAL CO (JP) 1995-09-20 EP claimed
US-5280010-A Using 1-amino-3-fluorophenylpyrimidine-2,4-dione SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-01-18 US claimed
EP-0517181-A1 Amino uracil derivatives, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-12-09 EP claimed
EP-0973395-B1 DIARYL ETHERS AND PROCESSES FOR THEIR PREPARATION AND HERBICIDAL AND DESICCANT COMPOSITIONS CONTAINING THEM ISK AMERICAS INC (US) 2003-12-03 EP disclosed
US-6479435-B1 OR DIARYL SULFIDES, 1-(4-CHLORO-2-FLUORO-5-(2-PYRIMIDYLOXY)PHENYL)-4-DIFLUOROMETHY L-3-METHYL-1,4-DIHYDRO-1,2,4-TRIAZOLIN-5-ONE FOR EXAMPLE ISK AMERICAS INCORPORATED 2002-11-12 US disclosed
US-20020161224-A1 Diaryl ethers and processes for their preparation and herbicidal and desiccant compositions containing them PULMAN DAVID A (US) 2002-10-31 US disclosed
US-6333296-B1 FOR CONTRILLING WEEDS ISK AMERICAS INCORPORATED 2001-12-25 US disclosed
US-6303543-B1 Diaryl ethers and processes for their preparation and herbicidal and desiccant compositions containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 2001-10-16 US disclosed
EP-0973395-A4 DIARYL ETHERS AND PROCESSES FOR THEIR PREPARATION AND HERBICIDAL AND DESICCANT COMPOSITIONS CONTAINING THEM ISK AMERICAS INC (US) 2001-10-04 EP disclosed
US-6121201-A HETEROARYL SUBSTITUTED HALO-PYRAZOLE SUBSTITUTED DIARYL ETHERS OR THIOETHERS ISHIHARA SANGYO KAISHA, LTD. (JP) 2000-09-19 US disclosed
EP-0973395-A1 DIARYL ETHERS AND PROCESSES FOR THEIR PREPARATION AND HERBICIDAL AND DESICCANT COMPOSITIONS CONTAINING THEM ISK Americas Incorporated (US) 2000-01-26 EP disclosed
WO-1998041093-A1 DIARYL ETHERS AND PROCESSES FOR THEIR PREPARATION AND HERBICIDAL AND DESICCANT COMPOSITIONS CONTAINING THEM ISK AMERICAS INCORPORATED (US) 1998-09-24 WO disclosed
EP-0517181-B1 Amino uracil derivatives, and their production and use SUMITOMO CHEMICAL CO (JP) 1995-09-20 EP disclosed
US-5280010-A Using 1-amino-3-fluorophenylpyrimidine-2,4-dione SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-01-18 US disclosed
EP-0517181-A1 Amino uracil derivatives, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-12-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020161224-A1 Diaryl ethers and processes for their preparation and herbicidal and desiccant compositions containing them HDHD5, DDT, CBR3 PPOX 1376/4885MEN1 4038/4885NR1I2 2910/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.