Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 4/20 | 0.39 |
| ▸ | PDE6C | P51160 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | PDE8A | O60658 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | PDE6A | P16499 | 1/20 | 0.38 |
| ▸ | PDE6G | P18545 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17333641 | 0.84 | PDE5A (0.47) | KMT2APDE5APDE6CMAPTPDE2A | |
| SCHEMBL3671939 | 0.82 | PDE5A (0.55) | PDE5APDE6CPDE2AABCC4ABCC5 | |
| SCHEMBL5085823 | 0.82 | PDE5A (0.56) | KMT2APDE5APDE6CMAPTPDE9A | |
| SCHEMBL7019550 | 0.79 | PDE5A (0.46) | KMT2ALRRK2NPSR1PDE5APDE6C | |
| SCHEMBL6433453 | 0.79 | NPSR1 (0.43) | PARP1KMT2ALRRK2NPSR1PDE5A | |
| SCHEMBL16972452 | 0.77 | PDE1A (0.48) | KMT2APDE5APDE6CMAPTPDE2A | |
| SCHEMBL7085453 | 0.77 | PDE5A (0.36) | KMT2APDE5APDE6CPDE2AABCC4 | |
| SCHEMBL5990273 | 0.77 | PDE5A (0.50) | PARP1KMT2APDE5APDE6CMAPT | |
| SCHEMBL4653201 | 0.75 | PDE5A (0.47) | PDE5APDE6CPDE2AABCC4ABCC5 | |
| SCHEMBL14685955 | 0.75 | KDM4E (0.41) | KMT2APDE5APDE6CPDE2AABCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276481-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | Lilly Icos LLC (US) | 2003-01-22 | — | — | EP | claimed |
| WO-2001080860-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | LILLY ICOS LLC (US) | 2001-11-01 | — | — | WO | claimed |
| EP-1276481-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | Lilly Icos LLC (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001080860-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | LILLY ICOS LLC (US) | 2001-11-01 | — | — | WO | disclosed |