SCHEMBL701976

SCHEMBL701976

CCn1c(C(=O)O)cc2ccccc21

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 4/20 0.69
ALDH1A1 P00352 2/20 0.64
CYP1A2 P05177 1/20 0.64
POLB P06746 1/20 0.64
MCL1 Q07820 4/20 0.62
GPR35 Q9HC97 1/20 0.61
DAO P14920 1/20 0.59
TSHR P16473 1/20 0.56
CA12 O43570 1/20 0.53
CA9 Q16790 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
FDPS P14324 1/20 0.50
PLA2G4A P47712 1/20 0.49
PPARG P37231 1/20 0.48
PLA2G10 O15496 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30067600 1.00 CCR2 (0.69) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL700800 0.87 ALDH1A1 (0.69) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL30044340 0.85 CCR2 (0.58) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL14259845 0.85 CCR2 (0.50) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL13738783 0.85 CCR2 (0.58) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL7463101 0.84 CCR2 (0.71) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL10757133 0.84 ALDH1A1 (0.66) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL6682164 0.83 ALDH1A1 (0.64) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL13701158 0.83 CCR2 (0.69) CCR2ALDH1A1CYP1A2POLBMCL1
SCHEMBL13305894 0.83 CCR2 (0.69) CCR2ALDH1A1CYP1A2POLBMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12378224-B2 Heteroaryl compounds and their use as Mer inhibitors DONG-A SOCIO HOLDINGS CO., LTD. (KR) 2025-08-05 US disclosed
US-20240383856-A1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2024-11-21 US disclosed
US-20240376055-A1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2024-11-14 US disclosed
US-20240317708-A1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2024-09-26 US disclosed
EP-4192812-B1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2024-09-04 EP disclosed
US-20240270715-A1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2024-08-15 US disclosed
EP-4192813-B1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2024-08-14 EP disclosed
EP-4192814-B1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2024-08-07 EP disclosed
CN-117616011-A Inhibitors of transglutaminase 策迪拉有限公司 2024-02-27 CN disclosed
CN-117561240-A Inhibitors of transglutaminase 策迪拉有限公司 2024-02-13 CN disclosed
EP-1226138-A1 FAB I INHIBITORS SmithKline Beecham Corporation (US) 2002-07-31 EP disclosed
WO-2001027103-A1 FAB I INHIBITORS SMITHKLINE BEECHAM CORPORATION (GB) 2001-04-19 WO disclosed
US-6214856-B1 TREATING NEURODEGENERATIVE DISORDERS, E.G., ALZHEIMER'S DISEASE, STROKES, TRAUMATIC BRAIN INJURY; ANTIISCHEMIC AGENTS; MUSCULAR DYSTROPHY; ALSO CATARACTS; PLATELET AGGREGATION SMITHKLINE BEECHAM CORPORATION 2001-04-10 US disclosed
EP-1018878-A4 NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN SMITHKLINE BEECHAM CORP (US) 2001-01-10 EP disclosed
EP-1018878-A1 NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN SmithKline Beecham Corporation (US) 2000-07-19 EP disclosed
WO-1998041092-A1 NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN SMITHKLINE BEECHAM CORPORATION (US) 1998-09-24 WO disclosed
US-5523411-A Synthesis of mitomycin and its analogs RUTGERS UNIVERSITY (US) 1996-06-04 US disclosed
US-4697018-A CARBONLESS DUPLICATION OR THERMAL MARKING DYES THE HILTON-DAVIS CHEMICAL CO. (US) 1987-09-29 US disclosed
US-4558137-A CHROMAGENS, PRESSURE AND HEAT SENSITIVE CARBONLESS DUPLICATING SYSTEMS THE HILTON-DAVIS CHEMICAL CO. (US) 1985-12-10 US disclosed
US-4403791-A Carbonless duplicating and marking systems STERLING DRUG INC. (US) 1983-09-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378224-B2 Heteroaryl compounds and their use as Mer inhibitors MERTK, RET, ERBB2 CCR2 1942/4885ALDH1A1 3864/4885CYP1A2 1346/4885
US-20240383856-A1 INHIBITORS OF TRANSGLUTAMINASES TGM2, TGM3, TGM1 CCR2 4801/4885ALDH1A1 1825/4885CYP1A2 714/4885
US-20240376055-A1 INHIBITORS OF TRANSGLUTAMINASES TGM2, TGM3, TGM1 CCR2 4801/4885ALDH1A1 1825/4885CYP1A2 714/4885
US-20240317708-A1 INHIBITORS OF TRANSGLUTAMINASES TGM2, TGM3, TGM1 CCR2 4801/4885ALDH1A1 1825/4885CYP1A2 714/4885
US-20240270715-A1 INHIBITORS OF TRANSGLUTAMINASES TGM2, TGM3, TGM1 CCR2 4801/4885ALDH1A1 1825/4885CYP1A2 714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.