Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017298 | 0.90 | TP53 (0.46) | LMNAMAPK1TP53TDP1SMN1; SMN2 | |
| SCHEMBL7015987 | 0.89 | TP53 (0.47) | LMNAMAPK1TP53TDP1TRPC5 | |
| SCHEMBL7016241 | 0.88 | SMN1; SMN2 (0.43) | LMNAMAPK1TP53TDP1SMN1; SMN2 | |
| SCHEMBL7020184 | 0.83 | TP53 (0.44) | LMNAMAPK1TP53TDP1TRPC5 | |
| SCHEMBL7021271 | 0.82 | CYP19A1 (0.41) | LMNAMAPK1TP53TDP1SMN1; SMN2 | |
| SCHEMBL7016056 | 0.81 | THRB (0.47) | TP53SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL7008880 | 0.81 | TP53 (0.37) | LMNAMAPK1TP53TDP1SMN1; SMN2 | |
| SCHEMBL7017354 | 0.80 | THRB (0.48) | TP53SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL7016238 | 0.79 | MAPT (0.43) | LMNAMAPK1TP53TDP1SMN1; SMN2 | |
| SCHEMBL7019393 | 0.79 | HTT (0.42) | TP53SMN1; SMN2KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |