Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 8/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7035440 | 0.84 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL7021108 | 0.83 | ALDH1A1 (0.41) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL6256894 | 0.81 | MMP13 (0.42) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6254110 | 0.79 | TRPA1 (0.48) | TRPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7105492 | 0.78 | HDAC8 (0.47) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6729378 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL6254904 | 0.76 | MAPK8 (0.41) | ALDH1A1PARGDPP4LMNA | |
| SCHEMBL7105942 | 0.76 | ADORA2B (0.48) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6446967 | 0.76 | MMP13 (0.38) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL7038890 | 0.76 | MMP13 (0.46) | TRPA1KDM4ESMN1; SMN2MAPTPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |