Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 11/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285249 | 0.81 | NR1H4 (0.63) | ALOX5NR1H4MAPTKDM4ETP53 | |
| SCHEMBL6285593 | 0.70 | NR1H4 (0.48) | ALOX5NR1H4MAPTKDM4EALDH1A1 | |
| SCHEMBL6285265 | 0.67 | NR1H4 (0.48) | ALOX5NR1H4 | |
| SCHEMBL15332882 | 0.66 | KDM4E (0.59) | ALOX5NR1H4MAPTKDM4EALDH1A1 | |
| SCHEMBL2556784 | 0.66 | PRNP (0.55) | ALOX5NR1H4MAPTKDM4EALDH1A1 | |
| SCHEMBL29956421 | 0.66 | PRNP (0.55) | ALOX5NR1H4MAPTKDM4EALDH1A1 | |
| SCHEMBL2611913 | 0.65 | ALOX5 (0.65) | ALOX5NR1H4MAPTKDM4EALDH1A1 | |
| SCHEMBL5421593 | 0.64 | NR1H4 (0.81) | ALOX5NR1H4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6389221 | 0.61 | RAB9A (0.97) | MAPTKDM4EALDH1A1TP53HPGD | |
| SCHEMBL2228417 | 0.61 | ALDH1A1 (0.69) | NR1H4MAPTKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | claimed |