SCHEMBL702237

SCHEMBL702237

CC(=O)Nc1ncc(C=c2sc(=CN=Nc3ccc(O)c(F)c3)[nH]c2=O)s1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
AOC3 Q16853 2/20 0.33
OGA O60502 12/20 0.32
MAPT P10636 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
LMNA P02545 2/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL702236 1.00 MEN1 (0.35) MEN1KMT2AAOC3OGAMAPT
SCHEMBL717617 0.85 OGA (0.38) MEN1KMT2AOGAMAPTLMNA
SCHEMBL705477 0.83 MEN1 (0.33) MEN1KMT2AAOC3LMNA
SCHEMBL705478 0.83 MEN1 (0.33) MEN1KMT2AAOC3LMNA
SCHEMBL702367 0.82 OGA (0.35) MEN1KMT2AOGAMAPTL3MBTL1
SCHEMBL702368 0.82 OGA (0.35) MEN1KMT2AOGAMAPTL3MBTL1
SCHEMBL704130 0.80 LMNA (0.34) MEN1KMT2AOGAMAPTLMNA
SCHEMBL704131 0.80 LMNA (0.34) MEN1KMT2AOGAMAPTLMNA
SCHEMBL702580 0.77 OGA (0.39) MEN1KMT2AOGAMAPTLMNA
SCHEMBL702579 0.77 OGA (0.39) MEN1KMT2AOGAMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423204-A1 THIAZOLIDINONE DERIVATIVE SBI Biotech Co., Ltd. (JP) 2012-02-29 EP disclosed