SCHEMBL702368

SCHEMBL702368

CC(=O)Nc1ncc(C=c2sc(=CN=Nc3ccccc3O)[nH]c2=O)s1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
OGA O60502 13/20 0.35
CCNE2 O96020 1/20 0.33
CCNE1 P24864 1/20 0.33
CDK2 P24941 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 1/20 0.32
ALOX12 P18054 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
DYRK1A Q13627 1/20 0.32
MAPT P10636 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL702367 1.00 OGA (0.35) OGACCNE2CCNE1CDK2MEN1
SCHEMBL717617 0.88 OGA (0.38) OGACCNE2CCNE1CDK2MEN1
SCHEMBL704131 0.84 LMNA (0.34) OGAMEN1KMT2ALMNAPOLB
SCHEMBL704130 0.84 LMNA (0.34) OGAMEN1KMT2ALMNAPOLB
SCHEMBL702236 0.82 MEN1 (0.35) OGAMEN1KMT2ALMNANPSR1
SCHEMBL702237 0.82 MEN1 (0.35) OGAMEN1KMT2ALMNANPSR1
SCHEMBL702580 0.81 OGA (0.39) OGAMEN1KMT2ALMNAHPGD
SCHEMBL702579 0.81 OGA (0.39) OGAMEN1KMT2ALMNAHPGD
SCHEMBL710896 0.78 KMT2A (0.40) OGAMEN1KMT2AMAPT
SCHEMBL705477 0.77 MEN1 (0.33) MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423204-A1 THIAZOLIDINONE DERIVATIVE SBI Biotech Co., Ltd. (JP) 2012-02-29 EP disclosed