Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27512418 | 0.78 | CTSK (0.36) | CTSKACACBMAPTCNR2TRPV1 | |
| SCHEMBL5870326 | 0.76 | EPHX1 (0.56) | EPHX1ACEMAPT | |
| SCHEMBL4446711 | 0.76 | EPHX1 (0.56) | EPHX1ACEMAPT | |
| SCHEMBL5870328 | 0.76 | EPHX1 (0.56) | EPHX1ACEMAPT | |
| SCHEMBL13677285 | 0.70 | CTSK (0.66) | EPHX1ACECTSKTRPV1 | |
| SCHEMBL13778157 | 0.65 | EPHX1 (0.61) | EPHX1ACE | |
| SCHEMBL7014082 | 0.65 | CTSL (0.35) | — | |
| SCHEMBL15317639 | 0.64 | ALDH1A1 (0.55) | MAPTMEN1KMT2A | |
| SCHEMBL22047379 | 0.62 | PIK3CD (0.35) | ACACBMEN1KMT2A | |
| SCHEMBL22854283 | 0.62 | MAPT (0.66) | MAPTCNR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |