Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.35 |
| ▸ | CTSS | P25774 | 4/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020376 | 0.81 | ALDH1A1 (0.40) | CTSLCTSSIL1BP2RX7 | |
| SCHEMBL27513468 | 0.73 | CTSL (0.35) | CTSLCTSSIL1BP2RX7PDE4A | |
| SCHEMBL6803771 | 0.69 | CTSS (0.54) | CTSLCTSS | |
| SCHEMBL5870525 | 0.69 | OPRK1 (0.33) | CTSLCTSSOPRK1 | |
| SCHEMBL4450179 | 0.69 | CTSS (0.49) | CTSLCTSS | |
| SCHEMBL6300240 | 0.68 | OPRK1 (0.32) | OPRK1 | |
| SCHEMBL7103226 | 0.66 | CTSS (0.46) | CTSLCTSS | |
| SCHEMBL28745325 | 0.65 | CTSL (0.35) | CTSLCTSSIL1BP2RX7PDE4A | |
| SCHEMBL7023832 | 0.65 | EPHX1 (0.44) | — | |
| SCHEMBL5870362 | 0.63 | SLC1A3 (0.50) | CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |