Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B known ✓ | P28222 | 4/20 | 0.59 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.59 |
| ▸ | HTR1D known ✓ | P28221 | 2/20 | 0.59 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL980209 | 0.94 | HTR1B (0.61) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL7031093 | 0.94 | HTR1B (0.61) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL2301469 | 0.94 | HTR1B (0.61) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Bromide SCHEMBL7027435 | 0.93 | HTR1B (0.60) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Hydrochloric Acid SCHEMBL3466984 | 0.93 | HTR1B (0.60) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Oxalic Acid SCHEMBL7540895 | 0.92 | HTR1B (0.62) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL7700352 | 0.89 | HTR1B (0.68) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL7024837 | 0.89 | HTR1B (0.68) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL16318529 | 0.88 | HTR1B (0.69) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL7025602 | 0.88 | HTR1B (0.69) | HTR1BHTR1AHTR1DDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674621-B1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | VERNALIS LTD (GB) | 2003-02-26 | — | — | EP | claimed |
| US-5616603-A | TREATING MIGRAINES | SMITHKLINE BEECHAM PLC (GB) | 1997-04-01 | — | — | US | claimed |
| EP-0674621-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | claimed |
| WO-1994014772-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | claimed |
| EP-0674621-B1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | VERNALIS LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-5962501-A | HEADACHES | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5917054-A | ALKYLATING ENANTIOMER OF 3-AMINO-6-CARBOXAMIDO-1,2,3,4-TETRAHYDROCARBAZOLE OR A SALT | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-06-29 | — | — | US | disclosed |
| US-5650426-A | Enantiomers of carbazole derivatives as 5-HT.sub. 1-like agonists | SMITHKLINE BEECHAM PLC (GB) | 1997-07-22 | — | — | US | disclosed |
| US-5618947-A | SEPARATING THE RACEMIC MIXTURE BY CHROMATOGRAPHY | SMITHKLINE BEECHAM, P.L.C. (GB) | 1997-04-08 | — | — | US | disclosed |
| US-5618948-A | TREATMENT OF 6-CARBOXAMIDO-3-METHYLAMINO-1,2,3,4-TETRAHYDROCARBAZOLE WITH 2-PYRROLIDONE-5-CARBOXYLIC ACID, CRYSTALLIZATION | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-04-08 | — | — | US | disclosed |
| US-5616603-A | TREATING MIGRAINES | SMITHKLINE BEECHAM PLC (GB) | 1997-04-01 | — | — | US | disclosed |