Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026213 | 1.00 | HTR3E (0.49) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL7027905 | 0.94 | CHEK1 (0.48) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL7027900 | 0.94 | CHEK1 (0.48) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL7031005 | 0.81 | MTNR1A (0.57) | MTNR1AMTNR1B | |
| SCHEMBL7031008 | 0.81 | MTNR1A (0.57) | MTNR1AMTNR1B | |
| SCHEMBL7027929 | 0.81 | MTNR1A (0.65) | MTNR1AMTNR1B | |
| SCHEMBL7027930 | 0.81 | MTNR1A (0.65) | MTNR1AMTNR1B | |
| SCHEMBL4787207 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1BUSP30 | |
| SCHEMBL7022199 | 0.77 | MTNR1A (0.60) | MTNR1AMTNR1B | |
| SCHEMBL7022204 | 0.77 | MTNR1A (0.60) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |