Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3044833 | 0.91 | CHRM5 (0.43) | CHRM5CHRM1GPR119ESR2MAPT | |
| SCHEMBL2781108 | 0.90 | CHRM5 (0.42) | PPARGPPARACHRM5CHRM1HPGD | |
| SCHEMBL3096155 | 0.86 | CHRM5 (0.39) | CHRM5CHRM1GPR119ESR2NR1H2 | |
| SCHEMBL1751975 | 0.81 | CYP3A4 (0.42) | PPARGPPARACHRM5CHRM1GPR119 | |
| SCHEMBL5941966 | 0.81 | ESR2 (0.39) | PPARGPPARACHRM5CHRM1GPR119 | |
| SCHEMBL5942256 | 0.81 | GRAMD1A (0.41) | PPARGPPARAGPR119ESR2MAPT | |
| SCHEMBL5941782 | 0.80 | GPR119 (0.36) | CHRM5CHRM1GPR119MAPTP2RX3 | |
| SCHEMBL6168033 | 0.80 | GPR119 (0.40) | CHRM5CHRM1GPR119P2RX3 | |
| SCHEMBL5941768 | 0.80 | GPR119 (0.39) | GPR119 | |
| SCHEMBL5942712 | 0.79 | ADAM17 (0.38) | PPARGPPARACHRM5CHRM1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004105738-A2 | USE OF TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-12-09 | — | — | WO | disclosed |