Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.52 |
| ▸ | CTSL | P07711 | 10/20 | 0.52 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | CTSB | P07858 | 4/20 | 0.48 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417185 | 0.91 | CTSL (0.57) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7422431 | 0.86 | CTSS (0.47) | CTSSCTSLCTSKCTSBGPR132 | |
| SCHEMBL7410718 | 0.82 | CTSS (0.47) | CTSSCTSLCTSKCTSBNPC1 | |
| SCHEMBL7409657 | 0.82 | CTSS (0.60) | CTSSCTSLCTSKCTSBGPR132 | |
| SCHEMBL7414009 | 0.81 | USP30 (0.46) | CTSSCTSLCTSKCTSBALDH1A1 | |
| SCHEMBL7414894 | 0.80 | CTSS (0.45) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7414674 | 0.79 | CTSS (0.45) | CTSSCTSLCTSKCTSBALDH1A1 | |
| SCHEMBL5528965 | 0.78 | CTSL (0.79) | CTSSCTSLCTSKCTSBGPR132 | |
| SCHEMBL5365066 | 0.75 | CTSS (0.57) | CTSSCTSLCTSKCTSBGPR132 | |
| SCHEMBL7423676 | 0.75 | CTSL (0.44) | CTSSCTSLCTSKCTSBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003529546-A | — | — | 2003-10-07 | — | — | JP | claimed |
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | claimed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | claimed |