Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 9/20 | 0.60 |
| ▸ | CTSL | P07711 | 8/20 | 0.60 |
| ▸ | CTSB | P07858 | 5/20 | 0.49 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.37 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417185 | 0.91 | CTSL (0.57) | CTSSCTSLCTSBCTSKGRN | |
| SCHEMBL7410718 | 0.89 | CTSS (0.47) | CTSSCTSLCTSBCTSKGRN | |
| SCHEMBL7414894 | 0.87 | CTSS (0.45) | CTSSCTSLCTSBCTSKGRN | |
| SCHEMBL7414674 | 0.85 | CTSS (0.45) | CTSSCTSLCTSBCTSKUSP30 | |
| SCHEMBL7026883 | 0.82 | CTSS (0.52) | CTSSCTSLCTSBCTSKGPR132 | |
| SCHEMBL7414009 | 0.82 | USP30 (0.46) | CTSSCTSLCTSBCTSKCHRNB2 | |
| SCHEMBL5528488 | 0.81 | CTSL (0.62) | CTSSCTSLCTSBCTSKGPR132 | |
| SCHEMBL7415423 | 0.77 | CTSS (0.43) | CTSSCTSLCTSBCTSKGRN | |
| SCHEMBL7414874 | 0.74 | CTSS (0.46) | CTSSCTSLCTSBCTSKCHRNB2 | |
| SCHEMBL5528491 | 0.74 | CTSL (0.81) | CTSSCTSLCTSBCTSKCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |