Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.51 |
| ▸ | MMP3 | P08254 | 4/20 | 0.51 |
| ▸ | MMP7 | P09237 | 3/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955404 | 0.90 | MMP1 (0.49) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL6075258 | 0.88 | MMP1 (0.47) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL6076854 | 0.82 | TAS2R14 (0.42) | MMP1MMP3MMP7MMP13HCRTR1 | |
| SCHEMBL6075816 | 0.78 | MMP1 (0.60) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL7362860 | 0.78 | MMP1 (0.41) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL8153443 | 0.77 | FKBP1A (0.55) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL8153446 | 0.77 | FKBP1A (0.55) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL7385275 | 0.77 | FKBP1A (0.55) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL7389960 | 0.76 | MMP1 (0.57) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL3717923 | 0.76 | MMP1 (0.73) | MMP1MMP3MMP7MMP13FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042297-B1 | CARBOXYL ACID SUBSTITUTED HETEROCYCLES AS METALLOPROTEINASE INHIBITORS | AMGEN INC (US) | 2003-02-26 | — | — | EP | claimed |
| US-6291450-B1 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use | AMGEN INC. | 2001-09-18 | — | — | US | disclosed |