Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 7/20 | 0.47 |
| ▸ | MMP1 | P03956 | 6/20 | 0.47 |
| ▸ | MMP9 | P14780 | 4/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034263 | 0.86 | L3MBTL1 (0.50) | MMP3MMP1MMP9ACEKMT2A | |
| SCHEMBL7032170 | 0.85 | ACE (0.50) | MMP3MMP1MMP9ACEKMT2A | |
| SCHEMBL7162745 | 0.76 | L3MBTL1 (0.51) | ACEKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL27041646 | 0.75 | CTSK (0.60) | MMP3MMP1MMP9ACECTSS | |
| SCHEMBL27041650 | 0.75 | CTSK (0.60) | MMP3MMP1MMP9ACECTSS | |
| SCHEMBL7101476 | 0.73 | L3MBTL1 (0.55) | MMP3MMP1MMP9ACEKMT2A | |
| SCHEMBL25320494 | 0.73 | HDAC8 (0.58) | ITGA4ITGB7CTSSCTSKALDH1A1 | |
| SCHEMBL28577595 | 0.72 | CTSS (0.60) | MMP3MMP1MMP9ACECTSS | |
| SCHEMBL25054064 | 0.72 | CTSS (0.60) | MMP3MMP1MMP9ACECTSS | |
| SCHEMBL22962029 | 0.72 | CTSS (0.59) | MMP3MMP1MMP9ACEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |