Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034263 | 0.93 | L3MBTL1 (0.50) | ACEMMP3ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL7027792 | 0.85 | MMP3 (0.47) | ACEMMP3ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL11019441 | 0.81 | EPHX1 (0.55) | MMP3ALDH1A1KMT2AL3MBTL1EPHX1 | |
| SCHEMBL18603491 | 0.77 | MMP3 (0.64) | ACEMMP3ALDH1A1KMT2AMMP1 | |
| SCHEMBL7101476 | 0.77 | L3MBTL1 (0.55) | ACEMMP3ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL7162745 | 0.75 | L3MBTL1 (0.51) | ACEALDH1A1KMT2AL3MBTL1EPHX1 | |
| SCHEMBL6401372 | 0.74 | ALDH1A1 (0.54) | MMP3ALDH1A1KMT2AFPR2SMN1; SMN2 | |
| SCHEMBL27349990 | 0.74 | ALDH1A1 (0.54) | MMP3ALDH1A1KMT2AFPR2SMN1; SMN2 | |
| SCHEMBL8315015 | 0.74 | ALDH1A1 (0.54) | MMP3ALDH1A1KMT2AFPR2SMN1; SMN2 | |
| SCHEMBL7033454 | 0.73 | MMP1 (0.45) | MMP3ALDH1A1L3MBTL1EPHX1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |