Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 7/20 | 0.41 |
| ▸ | MMP9 | P14780 | 7/20 | 0.41 |
| ▸ | MMP3 | P08254 | 6/20 | 0.41 |
| ▸ | MMP7 | P09237 | 4/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.38 |
| ▸ | MMP8 | P22894 | 4/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031074 | 0.93 | SMN1; SMN2 (0.50) | HCRTR1HCRTR2SMN1; SMN2PKMHTT | |
| SCHEMBL6075541 | 0.88 | HCRTR1 (0.47) | HCRTR1HCRTR2SMN1; SMN2PKMHTT | |
| SCHEMBL6076418 | 0.81 | SMN1; SMN2 (0.52) | HCRTR1HCRTR2SMN1; SMN2PKMHTT | |
| SCHEMBL6075529 | 0.78 | PKM (0.52) | SMN1; SMN2PKMHTTMMP1MMP9 | |
| SCHEMBL7422439 | 0.76 | MMP1 (0.57) | SMN1; SMN2PKMHTTMMP1MMP9 | |
| SCHEMBL6075725 | 0.74 | PKM (0.52) | SMN1; SMN2PKMHTTMMP1MMP9 | |
| SCHEMBL6075748 | 0.74 | PKM (0.49) | HCRTR1HCRTR2SMN1; SMN2PKMHTT | |
| SCHEMBL6075466 | 0.74 | PKM (0.47) | SMN1; SMN2PKMHTTMMP1MMP9 | |
| SCHEMBL6076126 | 0.72 | MMP3 (0.47) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7033779 | 0.70 | MMP1 (0.44) | SMN1; SMN2PKMMMP1MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042297-B1 | CARBOXYL ACID SUBSTITUTED HETEROCYCLES AS METALLOPROTEINASE INHIBITORS | AMGEN INC (US) | 2003-02-26 | — | — | EP | claimed |