SCHEMBL7029366

SCHEMBL7029366

[CH2]CSCc1ccc(OC)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
TP53 P04637 1/20 0.53
CYP3A4 P08684 1/20 0.53
ALOX15 P16050 1/20 0.53
TSHR P16473 1/20 0.53
ALOX12 P18054 1/20 0.53
IDO1 P14902 5/20 0.52
APP P05067 1/20 0.49
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
AGXT P21549 2/20 0.45
LTA4H P09960 1/20 0.45
TAAR1 Q96RJ0 1/20 0.45
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL62037 0.87 IDO1 (0.59) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
Hydrochloric Acid SCHEMBL5797813 0.85 IDO1 (0.60) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL6624910 0.85 IDO1 (0.57) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL7554673 0.82 TSHR (0.37) ALDH1A1TP53CYP3A4ALOX15TSHR
SCHEMBL12308295 0.81 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL1127531 0.79 LTA4H (0.67) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL728403 0.79 IDO1 (0.56) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL1145765 0.78 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL769511 0.78 IDO1 (0.59) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL10064850 0.78 IDO1 (0.55) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0977730-B1 AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE CHIESI FARMA SPA (IT) 2003-03-12 EP disclosed
EP-0977730-A1 AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE CHIESI FARMACEUTICI S.p.A. (IT) 2000-02-09 EP disclosed
WO-1998047863-A1 AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE CHIESI FARMACEUTICI S.P.A. (IT) 1998-10-29 WO disclosed