SCHEMBL7029971

SCHEMBL7029971

Cc1nnc(N)n(N)c1=O

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.55
KDM4E B2RXH2 3/20 0.55
MAPT P10636 3/20 0.55
POLB P06746 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.43
HTT P42858 1/20 0.37
RAB9A P51151 2/20 0.36
GAA P10253 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
KMT2A Q03164 1/20 0.34
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11721857 0.74 ALDH1A1 (0.53) ALDH1A1KDM4EMAPTPOLBL3MBTL1
SCHEMBL7028443 0.71 KDM4E (0.33) ALDH1A1KDM4EMAPTGAALMNA
SCHEMBL7023893 0.71 POLB (0.34) POLBGAA
SCHEMBL10599397 0.71 POLB (0.65) ALDH1A1KDM4EMAPTPOLBHTT
Hydrochloric Acid SCHEMBL7029949 0.70 POLB (0.33) POLBGAA
Hydrochloric Acid SCHEMBL7031307 0.70 GAA (0.33) ALDH1A1KDM4EMAPTGAA
Hydrochloric Acid SCHEMBL7023278 0.70 ALDH1A1 (0.96) ALDH1A1KDM4EMAPTPOLBL3MBTL1
SCHEMBL10833000 0.70 KDM4E (0.35) ALDH1A1KDM4EMAPTPOLBRAB9A
SCHEMBL373770 0.69
SCHEMBL7144640 0.67 ALDH1A1 (0.33) ALDH1A1KDM4EMAPTPOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889884-B1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON INC (US) 2003-01-29 EP claimed
US-6380192-B1 FOR INHIBITING NONENZYMATIC CROSS-LINKING (PROTEIN AGING) ALTEON, INC. 2002-04-30 US claimed
US-5932578-A CAPABLE OF INHIBITING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS OF TARGET PROTEINS. FOOD SPOILAGE AND ANIMAL PROTEIN AGING CAN BE TREATED. ALTEON INC. (US) 1999-08-03 US claimed
EP-0889884-A1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON, INC. (US) 1999-01-13 EP claimed
WO-1997035849-A1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON INC. (US) 1997-10-02 WO claimed
EP-0889884-B1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON INC (US) 2003-01-29 EP disclosed
US-6380192-B1 FOR INHIBITING NONENZYMATIC CROSS-LINKING (PROTEIN AGING) ALTEON, INC. 2002-04-30 US disclosed
US-6060470-A Triazine compounds and methods of use therefor ALTEON, INC. 2000-05-09 US disclosed
US-5932578-A CAPABLE OF INHIBITING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS OF TARGET PROTEINS. FOOD SPOILAGE AND ANIMAL PROTEIN AGING CAN BE TREATED. ALTEON INC. (US) 1999-08-03 US disclosed
EP-0889884-A1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON, INC. (US) 1999-01-13 EP disclosed
WO-1997035849-A1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON INC. (US) 1997-10-02 WO disclosed