Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | CES1 | P23141 | 5/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16812540 | 0.88 | DRD2 (0.35) | DRD2CES1HTR1DDRD3 | |
| SCHEMBL9007737 | 0.88 | DRD2 (0.48) | DRD2CES1HTR1DDRD3 | |
| SCHEMBL7107742 | 0.85 | DRD2 (0.36) | DRD2CES1HTR1DDRD3 | |
| SCHEMBL23336944 | 0.85 | DRD2 (0.38) | DRD2CES1HTR1DDRD3 | |
| SCHEMBL7027415 | 0.84 | DRD2 (0.37) | DRD2CES1HTR1DDRD3 | |
| SCHEMBL1506665 | 0.84 | DRD2 (0.37) | DRD2CES1HTR1DDRD3 | |
| SCHEMBL15203251 | 0.82 | DRD2 (0.36) | DRD2HTR1DDRD3 | |
| SCHEMBL12533492 | 0.82 | DRD2 (0.38) | DRD2HTR1DDRD3 | |
| SCHEMBL1820878 | 0.81 | DRD2 (0.53) | DRD2HTR1DDRD3 | |
| SCHEMBL14972506 | 0.80 | DRD2 (0.35) | DRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512155-B2 | Chiral phosphines for palladium-catalyzed asymmetric α-arylation of ester enolates to produce tertiary stereocenters in high enantioselectivity | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-12-06 | — | — | US | disclosed |
| US-9512155-B2 | Chiral phosphines for palladium-catalyzed asymmetric α-arylation of ester enolates to produce tertiary stereocenters in high enantioselectivity | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-12-06 | — | — | US | disclosed |
| US-9512155-B2 | Chiral phosphines for palladium-catalyzed asymmetric α-arylation of ester enolates to produce tertiary stereocenters in high enantioselectivity | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-12-06 | — | — | US | disclosed |
| US-20150166586-A1 | CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ALPHA-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2015-06-18 | — | — | US | disclosed |
| US-20150166586-A1 | CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ALPHA-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2015-06-18 | — | — | US | disclosed |
| US-20150166586-A1 | CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ALPHA-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2015-06-18 | — | — | US | disclosed |
| WO-2013028132-A9 | CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ALPHA-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2013-08-22 | — | — | WO | disclosed |
| WO-2013028132-A1 | CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ALPHA-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2013-02-28 | — | — | WO | disclosed |
| EP-0839819-B1 | Method of preparing optically active diphosphine ligands | TAKASAGO PERFUMERY CO LTD (JP) | 2003-09-17 | — | — | EP | disclosed |
| EP-0684249-B1 | Phosphine compounds, complexes containing the phosphine compounds as ligands, and process for producing optically active aldehydes using the phosphine compounds or complexes | TAKASAGO PERFUMERY CO LTD (JP) | 2003-02-19 | — | — | EP | disclosed |
| EP-0684230-B1 | 4- (R)-1'-formylethyl azetidin-2-one derivatives | TAKASAGO PERFUMERY CO LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0614903-B1 | Process for producing optically active aldehydes using transition metal-phosphine complexes, and process for producing intermediates for carbapenem antibiotics using the same complexes | TAKASAGO PERFUMERY CO LTD (JP) | 2000-09-20 | — | — | EP | disclosed |
| US-5922918-A | Method for making an optically active diphosphine ligand | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1999-07-13 | — | — | US | disclosed |
| EP-0839819-A1 | Method of preparing optically active diphosphine ligands | Takasago International Corporation (JP) | 1998-05-06 | — | — | EP | disclosed |
| EP-0614902-B1 | Phosphine compounds and transition metal-phosphine complexes containing them as ligands | TAKASAGO PERFUMERY CO LTD (JP) | 1997-06-11 | — | — | EP | disclosed |
| US-5530150-A | HAVING PHOSPHINE AND PHOSPHITE GROUPS IN SAME MOLECULE; CATALYST SELECTIVITY | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0684249-A1 | Phosphine compounds, complexes containing the phosphine compounds as ligands, and process for producing optically active aldehydes using the phosphine compounds or complexes | Takasago International Corporation (JP) | 1995-11-29 | — | — | EP | disclosed |
| EP-0684230-A1 | 4- (R)-1'-formylethyl azetidin-2-one derivatives | Takasago International Corporation (JP) | 1995-11-29 | — | — | EP | disclosed |
| EP-0614902-A1 | Phosphine compounds and transition metal-phosphine complexes containing them as ligands | Takasago International Corporation (JP) | 1994-09-14 | — | — | EP | disclosed |
| EP-0614903-A2 | Phosphine compounds, complexes containing the phosphine compounds as ligands, process for producing optically active aldehydes using the phosphine compounds, or complexes, and 4-[(R)-1' formylethyl]azetidin-2-one derivatives | Takasago International Corporation (JP) | 1994-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166586-A1 | CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ALPHA-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY | EPHA8, DAGLA, TEC | DRD2 2230/4885CES1 1096/4885HTR1D 2779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.