Sugi Predict

Sugi Predict / Compounds / SCHEMBL70303

SCHEMBL70303

SCHEMBL70303

O=C(O)c1cn(C2CC2)nn1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ SMYD3 Q9H7B4 2/20 0.55
▸ PSMB8 P28062 8/20 0.46
▸ PSMB5 P28074 8/20 0.46
▸ PSMB9 P28065 4/20 0.46
▸ RORC P51449 1/20 0.44
▸ SMYD2 Q9NRG4 2/20 0.41
▸ KDM6B O15054 2/20 0.40
▸ KDM5C P41229 2/20 0.40
▸ KDM4C Q9H3R0 2/20 0.40
▸ KDM2A Q9Y2K7 2/20 0.40
▸ KDM4A O75164 1/20 0.40
▸ DPP4 P27487 1/20 0.38
▸ KDM3A Q9Y4C1 1/20 0.38
▸ HDAC3 O15379 1/20 0.38
▸ HDAC1 Q13547 1/20 0.38
▸ HDAC2 Q92769 1/20 0.38
▸ HDAC8 Q9BY41 1/20 0.38
▸ HDAC6 Q9UBN7 1/20 0.38
▸ HCAR3 P49019 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL71503 0.93 PSMB8 (0.53) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL23921589 0.92 SMYD3 (0.68) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL2636030 0.88 ROCK2 (0.47) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL26052869 0.88 SMYD3 (0.46) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL1058260 0.87 GSK3B (0.46) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL19132794 0.85 RORC (0.46) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL31124040 0.84 SMYD3 (0.41) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL25243541 0.84 SMYD3 (0.41) SMYD3PSMB8PSMB5PSMB9RORC
SCHEMBL19691215 0.83 SMYD3 (0.57) SMYD3PSMB8PSMB5PSMB9SMYD2
SCHEMBL2636620 0.82 KDM2B (0.41) SMYD3PSMB8PSMB5PSMB9RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129376-B2 Piperidine derivatives as inhibitors of stearoyl-CoA desaturase AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2012-03-06 — — US claimed
WO-2010075356-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-07-01 — — WO claimed
US-20100160323-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-06-24 — — US claimed
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 — — US claimed
WO-2009117676-A2 NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 — — WO claimed
WO-2025137605-A1 COMPOUNDS FOR TARGETED DEGRADATION OF PROTO-ONCOGENE TYROSINE PROTEIN KINASE RECEPTOR C4 THERAPEUTICS, INC. (US) 2025-06-26 — — WO disclosed
CN-117777102-A BTK inhibitor and preparation method and application thereof 南方医科大学 2024-03-29 — — CN disclosed
US-20230101819-A1 SMYD Inhibitors EPIZYME INC (US) 2023-03-30 — — US disclosed
CN-115028619-A SMYD inhibitors EPIZYME股份有限公司 2022-09-09 — — CN disclosed
CN-107072205-B SMYD inhibitors EPIZYME股份有限公司 2022-07-15 — — CN disclosed
US-20210198252-A1 SMYD INHIBITORS EPIZYME INC (US) 2021-07-01 — — US disclosed
US-20210198252-A1 SMYD INHIBITORS EPIZYME INC (US) 2021-07-01 — — US disclosed
WO-2016040505-A1 SMYD INHIBITORS Epizyme, Inc. (US) 2016-03-17 — — WO disclosed
US-8129376-B2 Piperidine derivatives as inhibitors of stearoyl-CoA desaturase AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2012-03-06 — — US disclosed
CN-102036558-A Novel piperidine derivatives as stearoyl-CoA desaturase inhibitors FOREST LAB HOLDINGS LTD 2011-04-27 — — CN disclosed
EP-2268143-A2 NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE Forest Laboratories Holdings Limited (BM) 2011-01-05 — — EP disclosed
WO-2010075356-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-07-01 — — WO disclosed
US-20100160323-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-06-24 — — US disclosed
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 — — US disclosed
WO-2009117676-A2 NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100160323-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE SCD, SCD5, FADS2 SMYD3 302/4885PSMB8 3575/4885PSMB5 1370/4885
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE SCD, SCD5, FADS2 SMYD3 269/4885PSMB8 3624/4885PSMB5 1587/4885
US-20210198252-A1 SMYD INHIBITORS SMYD3, SMYD2, SMURF2 SMYD3 1/4885PSMB8 2612/4885PSMB5 1713/4885
US-20230101819-A1 SMYD Inhibitors SMYD3, SMYD2, SMURF2 SMYD3 1/4885PSMB8 2655/4885PSMB5 1764/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.