Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 8/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 8/20 | 0.53 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.53 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70303 | 0.93 | SMYD3 (0.55) | PSMB8PSMB5PSMB9SMYD3RORC | |
| SCHEMBL23921589 | 0.85 | SMYD3 (0.68) | PSMB8PSMB5PSMB9SMYD3RORC | |
| SCHEMBL2636030 | 0.85 | ROCK2 (0.47) | PSMB8PSMB5PSMB9SMYD3RORC | |
| SCHEMBL26052869 | 0.85 | SMYD3 (0.46) | PSMB8PSMB5PSMB9SMYD3RORC | |
| SCHEMBL1058260 | 0.83 | GSK3B (0.46) | PSMB8PSMB5PSMB9SMYD3RORC | |
| SCHEMBL18850877 | 0.83 | PSMB8 (0.54) | PSMB8PSMB5PSMB9SMYD3ACHE | |
| SCHEMBL18850919 | 0.83 | PSMB8 (0.54) | PSMB8PSMB5PSMB9SMYD3ACHE | |
| SCHEMBL19132794 | 0.82 | RORC (0.46) | PSMB8PSMB5PSMB9SMYD3RORC | |
| SCHEMBL31124040 | 0.81 | SMYD3 (0.41) | PSMB8PSMB5PSMB9SMYD3RORC | |
| SCHEMBL25243541 | 0.81 | SMYD3 (0.41) | PSMB8PSMB5PSMB9SMYD3RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129376-B2 | Piperidine derivatives as inhibitors of stearoyl-CoA desaturase | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-03-06 | — | — | US | claimed |
| WO-2010075356-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-07-01 | — | — | WO | claimed |
| US-20100160323-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-06-24 | — | — | US | claimed |
| WO-2009117676-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | WO | claimed |
| US-20090239810-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | US | claimed |
| US-10973810-B2 | Methods for the treatment of neurological disorders | YUMANITY THERAPEUTICS, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-10487063-B2 | Preparation method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid | ABA CHEMICALS (SHANGHAI) LIMITED (CN) | 2019-11-26 | — | — | US | disclosed |
| US-10487063-B2 | Preparation method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid | ABA CHEMICALS (SHANGHAI) LIMITED (CN) | 2019-11-26 | — | — | US | disclosed |
| EP-3566055-A1 | METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Yumanity Therapeutics, Inc. (US) | 2019-11-13 | — | — | EP | disclosed |
| US-20180193325-A1 | METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-07-12 | — | — | US | disclosed |
| WO-2018129403-A1 | METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | YUMANITY THERAPEUTICS (US) | 2018-07-12 | — | — | WO | disclosed |
| US-20180029999-A1 | Preparation Method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid | ABA CHEMICALS (SHANGHAI) LIMITED (CN) | 2018-02-01 | — | — | US | disclosed |
| US-20180029999-A1 | Preparation Method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid | ABA CHEMICALS (SHANGHAI) LIMITED (CN) | 2018-02-01 | — | — | US | disclosed |
| US-8129376-B2 | Piperidine derivatives as inhibitors of stearoyl-CoA desaturase | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-03-06 | — | — | US | disclosed |
| CN-102036558-A | Novel piperidine derivatives as stearoyl-CoA desaturase inhibitors | FOREST LAB HOLDINGS LTD | 2011-04-27 | — | — | CN | disclosed |
| EP-2268143-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | Forest Laboratories Holdings Limited (BM) | 2011-01-05 | — | — | EP | disclosed |
| WO-2010075356-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-07-01 | — | — | WO | disclosed |
| US-20100160323-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-06-24 | — | — | US | disclosed |
| WO-2009117676-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | WO | disclosed |
| US-20090239810-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160323-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | PSMB8 3575/4885PSMB5 1370/4885PSMB9 4089/4885 |
| US-10973810-B2 | Methods for the treatment of neurological disorders | NLN, CLN6, OTC | PSMB8 3899/4885PSMB5 2390/4885PSMB9 4264/4885 |
| US-20090239810-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | PSMB8 3624/4885PSMB5 1587/4885PSMB9 3948/4885 |
| US-20180193325-A1 | METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NLN, CLN6, OTC | PSMB8 3899/4885PSMB5 2390/4885PSMB9 4264/4885 |
| US-10487063-B2 | Preparation method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid | CLIC1, GRIK1, CA3 | PSMB8 4231/4885PSMB5 4507/4885PSMB9 3806/4885 |
| US-20180029999-A1 | Preparation Method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid | CLIC1, GRIK1, CA3 | PSMB8 4231/4885PSMB5 4507/4885PSMB9 3806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.