Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26330804 | 0.85 | HPGD (0.72) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL9911025 | 0.81 | HPGD (0.52) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL14303692 | 0.80 | HPGD (0.61) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL8405468 | 0.79 | HPGD (0.52) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL8696411 | 0.79 | POLB (0.73) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL8824043 | 0.77 | HPGD (0.55) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL27772020 | 0.77 | ALDH1A1 (0.69) | KMT2AMEN1CYP3A4CYP2C19GAA | |
| SCHEMBL5680025 | 0.77 | HPGD (0.54) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL2596926 | 0.77 | ALDH1A1 (0.69) | KMT2AMEN1CYP3A4CYP2C19GAA | |
| SCHEMBL14826382 | 0.76 | GAA (0.69) | HPGDKMT2AMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124766-B2 | Inhibitors of diacylglycerol acyltransferase | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-20100145047-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MADRIGAL PHARMACEUTICALS, INC. | 2010-06-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145047-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | HPGD 818/4885KMT2A 1436/4885MEN1 3609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.