SCHEMBL7031322

SCHEMBL7031322

CCOC(=O)CCc1nnc(N)n(N)c1=O

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
ALDH1A1 P00352 6/20 0.43
KDM4E B2RXH2 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP4F2 P78329 2/20 0.38
CYP4A11 Q02928 2/20 0.38
MAPK1 P28482 1/20 0.37
CYP1A2 P05177 1/20 0.37
TNF P01375 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.34
MAPT P10636 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7030321 0.99 LMNA (0.45) LMNAALDH1A1KDM4EHSD17B10CYP4F2
Hydrochloric Acid SCHEMBL8517214 0.88 TBXAS1 (0.41) LMNAALDH1A1CYP4F2CYP4A11CYP1A2
Hydrochloric Acid SCHEMBL7021156 0.77 ALDH1A1 (0.42) ALDH1A1KDM4EHSD17B10SMN1; SMN2
SCHEMBL7028443 0.72 KDM4E (0.33) LMNAALDH1A1KDM4EMAPT
SCHEMBL11716159 0.70 SMN1; SMN2 (0.43) ALDH1A1KDM4EHSD17B10MAPK1L3MBTL1
SCHEMBL13125915 0.64 ALDH1A1 (0.61) LMNAALDH1A1KDM4EHSD17B10CYP1A2
SCHEMBL11418576 0.64 POLB (0.64) ALDH1A1HSD17B10SMN1; SMN2
SCHEMBL20268795 0.63 MAPK1 (0.73) ALDH1A1KDM4EHSD17B10MAPK1CYP1A2
SCHEMBL11529284 0.63 ALDH1A1 (0.42) LMNAALDH1A1KDM4EHSD17B10CYP4F2
SCHEMBL25307852 0.62 CYP4F2 (0.43) LMNAALDH1A1KDM4EHSD17B10CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889884-B1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON INC (US) 2003-01-29 EP claimed
US-6380192-B1 FOR INHIBITING NONENZYMATIC CROSS-LINKING (PROTEIN AGING) ALTEON, INC. 2002-04-30 US claimed
EP-0889884-B1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON INC (US) 2003-01-29 EP disclosed
US-6380192-B1 FOR INHIBITING NONENZYMATIC CROSS-LINKING (PROTEIN AGING) ALTEON, INC. 2002-04-30 US disclosed
US-6060470-A Triazine compounds and methods of use therefor ALTEON, INC. 2000-05-09 US disclosed
US-5932578-A CAPABLE OF INHIBITING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS OF TARGET PROTEINS. FOOD SPOILAGE AND ANIMAL PROTEIN AGING CAN BE TREATED. ALTEON INC. (US) 1999-08-03 US disclosed
EP-0889884-A1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON, INC. (US) 1999-01-13 EP disclosed
WO-1997035849-A1 1,2,4-TRIAZINE DERIVATIVES FOR THE INHIBITION OF PROTEIN GLYCOSYLATION ALTEON INC. (US) 1997-10-02 WO disclosed