Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12341798 | 0.84 | ACHE (0.52) | PDCD1CD274ACHEALDH1A1CYP3A4 | |
| SCHEMBL697285 | 0.83 | ACHE (0.56) | PDCD1CD274ACHEPDE4APDE4B | |
| SCHEMBL22566468 | 0.83 | ACHE (0.60) | ACHEALDH1A1CYP3A4L3MBTL1MAPT | |
| SCHEMBL27324336 | 0.82 | PDCD1 (0.39) | PDCD1CD274ACHEPDE4APDE4B | |
| SCHEMBL15462235 | 0.81 | PDCD1 (0.40) | PDCD1CD274ACHEPDE4APDE4B | |
| SCHEMBL12259237 | 0.81 | ACHE (0.48) | PDCD1CD274ACHEPDE4APDE4B | |
| SCHEMBL1922960 | 0.81 | ACHE (0.48) | PDCD1CD274ACHEALDH1A1CYP3A4 | |
| SCHEMBL10187102 | 0.81 | L3MBTL1 (0.60) | ACHEALDH1A1CYP3A4L3MBTL1MAPT | |
| SCHEMBL11962350 | 0.80 | MAPT (0.45) | PDCD1CD274ACHEALDH1A1L3MBTL1 | |
| SCHEMBL806312 | 0.80 | PDE4A (0.61) | PDCD1CD274ACHEPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160977-A2 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | The University of Kansas (US) | 2017-05-03 | — | — | EP | claimed |
| WO-2015200514-A2 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | THE UNIVERSITY OF KANSAS (US) | 2015-12-30 | — | — | WO | claimed |
| EP-4393937-A1 | STEROID COMPOUND AND CONJUGATE THEREOF | Duality Biologics (Suzhou) Co., Ltd. (CN) | 2024-07-03 | — | — | EP | disclosed |
| US-11708319-B2 | Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers | UNIVERSITY OF KANSAS (US) | 2023-07-25 | — | — | US | disclosed |
| US-20220041543-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | REATA PHARMACEUTICALS, INC. | 2022-02-10 | — | — | US | disclosed |
| WO-2021262587-A1 | QUATERNARY INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS | CORCEPT THERAPEUTICS INCORPORATED (US) | 2021-12-30 | — | — | WO | disclosed |
| EP-3763367-A1 | PYRIDINE-PYRAZOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3763367-A1 | PYRIDINE-PYRAZOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-2928471-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2020-10-14 | — | — | EP | disclosed |
| EP-2928471-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2020-10-14 | — | — | EP | disclosed |
| US-20200270201-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | REATA PHARMACEUTICALS, INC. | 2020-08-27 | — | — | US | disclosed |
| US-7592362-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-09-22 | — | — | US | disclosed |
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | disclosed |
| US-7544706-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-09 | — | — | US | disclosed |
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-22 | — | — | US | disclosed |
| US-20080114002-A1 | Substituted Acids for the Treatment of Respiratory Diseases | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | US | disclosed |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | PFIZER INC. (US) | 2007-07-19 | — | — | US | disclosed |
| US-5158597-A | Herbicidal 12-substituted 12H-dibenzo[d,g]dioxocin-6-carboxylic acids | THE DOW CHEMICAL COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0403026-A1 | 12-Substituted-12H-dibenzo(D,G)(1,3)dioxocin-6-carboxylic acids, herbicidal compositions, and a method of controlling undesirable vegetation | DowElanco (US) | 1990-12-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | PDCD1 3313/4885CD274 3893/4885ACHE 230/4885 |
| US-11708319-B2 | Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers | HSP90AB2P, HSP90AB1, HSPB1 | PDCD1 2723/4885CD274 2965/4885ACHE 1551/4885 |
| US-20220041543-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | HSP90AB2P, HSP90AB1, HSPB1 | PDCD1 2723/4885CD274 2965/4885ACHE 1551/4885 |
| US-20200270201-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | HSP90AB2P, HSP90AB1, HSPB1 | PDCD1 2723/4885CD274 2965/4885ACHE 1551/4885 |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | PDCD1 3313/4885CD274 3893/4885ACHE 230/4885 |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | PDCD1 3313/4885CD274 3893/4885ACHE 230/4885 |
| US-20080114002-A1 | Substituted Acids for the Treatment of Respiratory Diseases | HRH2, HRH1, HRH4 | PDCD1 4760/4885CD274 4723/4885ACHE 4139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.