Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10353910 | 0.98 | ALOX15 (0.56) | ALOX15CYP1A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11785192 | 0.80 | ADRA2A (0.43) | ALOX15CYP1A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11787434 | 0.80 | HTR1D (0.46) | ALOX15CYP1A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11785989 | 0.80 | POLB (0.50) | CYP1A2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL11785205 | 0.80 | ADRA2A (0.45) | CYP1A2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL11783011 | 0.80 | ADRA2A (0.46) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL11787437 | 0.80 | HTR1D (0.46) | ALOX15CYP1A2NPC1RAB9ASMN1; SMN2 | |
| Water SCHEMBL11782383 | 0.80 | ADRA2A (0.45) | CYP1A2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL11786023 | 0.80 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Water SCHEMBL11782373 | 0.80 | ADRA2A (0.43) | ALOX15CYP1A2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022927-A1 | Novel benzimidazole derivatives | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-01-30 | — | — | US | disclosed |
| EP-0775134-A1 | Imidazolin-2-ylaminobenzimidazole derivatives | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-28 | — | — | EP | disclosed |
| US-3935314-A | Anti-hypertensive compositions of benzimidazole derivatives | BEECHAM GROUP LIMITED (EN) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030022927-A1 | Novel benzimidazole derivatives | OPRL1, OPRD1, OPRM1 | ALOX15 3708/4885CYP1A2 620/4885NPC1 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.