SCHEMBL703364

SCHEMBL703364

CC(C)(C)[Si](Br)(c1ccccc1)C(C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.34
ESR2 Q92731 3/20 0.34
MAPK1 P28482 1/20 0.33
NR1H2 P55055 2/20 0.32
NR1H3 Q13133 2/20 0.32
MAPT P10636 1/20 0.31
ALDH1A1 P00352 3/20 0.31
TAAR1 Q96RJ0 2/20 0.31
ALOX15 P16050 1/20 0.31
SLC6A2 P23975 1/20 0.31
LMNA P02545 1/20 0.30
TSHR P16473 1/20 0.30
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
ATM Q13315 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL705909 0.79 MAPK1 (0.39) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL708032 0.79 NR1H2 (0.36) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL29873256 0.74 ESR1 (0.34) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL3526796 0.72 ESR1 (0.37) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL3888384 0.72 ESR1 (0.37) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL29749402 0.72 ESR1 (0.37) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL20328588 0.72 ESR1 (0.37) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL1203382 0.72 MAPK1 (0.33) ESR1ESR2MAPK1ALDH1A1ALOX15
SCHEMBL8381381 0.70 TAAR1 (0.37) ESR1ESR2MAPK1NR1H2NR1H3
SCHEMBL15889153 0.70 ESR1 (0.41) ESR1ESR2MAPK1NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104974184-B preparation of silazane Compounds 信越化学工业株式会社 2019-12-06 CN disclosed
EP-2930177-B1 PREPARATION OF SILAZANE COMPOUND SHINETSU CHEMICAL CO (JP) 2018-04-25 EP disclosed
US-9416147-B2 Preparation of silazane compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 2016-08-16 US disclosed
EP-2930177-A1 Preparation of silazane compound Shin-Etsu Chemical Co., Ltd. (JP) 2015-10-14 EP disclosed
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 2015-10-08 US disclosed
US-8124239-B2 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2012-02-28 US disclosed
US-20100155121-A1 SILICA FILM FORMING MATERIAL, SILICA FILM AND METHOD OF MANUFACTURING THE SAME, MULTILAYER WIRING STRUCTURE AND METHOD OF MANUFACTURING THE SAME, AND SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME FUJITSU LIMITED (JP) 2010-06-24 US disclosed
US-7659357-B2 Precursor organosilicon polymer of 1,2-Bis(dimethylethoxysilyl)ethane, 1,4-bis(dimethylethoxysilyl)benzene, tetraethoxysilane, methyltriethoxysilane, phenyltriethoxysilane; dielectric (DE) films having etching/chemical/moisture resistance; adhesion; low DE constant; minimal wiring delay; high speed FUJITSU LIMITED (JP) 2010-02-09 US disclosed
US-20070026689-A1 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2007-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SLTM, SKP2, BCAT2 ESR1 4051/4885ESR2 4438/4885MAPK1 1333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.