SCHEMBL705909

SCHEMBL705909

CC(C)(C)[Si](Br)(Br)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.39
ALDH1A1 P00352 4/20 0.36
ALOX15 P16050 1/20 0.36
ESR1 P03372 3/20 0.34
ESR2 Q92731 3/20 0.34
NR1H2 P55055 2/20 0.32
NR1H3 Q13133 2/20 0.32
CA4 P22748 1/20 0.32
MAPT P10636 1/20 0.31
TAAR1 Q96RJ0 2/20 0.31
SLC6A2 P23975 1/20 0.31
TSHR P16473 2/20 0.30
TDP1 Q9NUW8 2/20 0.30
LMNA P02545 1/20 0.30
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30
HSD17B10 Q99714 1/20 0.30
ATM Q13315 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL704536 0.86 NR1H2 (0.32) NR1H2NR1H3
SCHEMBL703364 0.79 ESR1 (0.34) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL708032 0.79 NR1H2 (0.36) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL1203382 0.77 MAPK1 (0.33) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL7024842 0.73 MAPK1 (0.34) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL3526796 0.72 ESR1 (0.37) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL20328588 0.72 ESR1 (0.37) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL29749402 0.72 ESR1 (0.37) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL3888384 0.72 ESR1 (0.37) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL15888456 0.72 MAPK1 (0.37) MAPK1ALDH1A1ALOX15ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104974184-B preparation of silazane Compounds 信越化学工业株式会社 2019-12-06 CN disclosed
EP-2930177-B1 PREPARATION OF SILAZANE COMPOUND SHINETSU CHEMICAL CO (JP) 2018-04-25 EP disclosed
US-9416147-B2 Preparation of silazane compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 2016-08-16 US disclosed
EP-2930177-A1 Preparation of silazane compound Shin-Etsu Chemical Co., Ltd. (JP) 2015-10-14 EP disclosed
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 2015-10-08 US disclosed
US-8124239-B2 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2012-02-28 US disclosed
US-20100155121-A1 SILICA FILM FORMING MATERIAL, SILICA FILM AND METHOD OF MANUFACTURING THE SAME, MULTILAYER WIRING STRUCTURE AND METHOD OF MANUFACTURING THE SAME, AND SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME FUJITSU LIMITED (JP) 2010-06-24 US disclosed
US-7659357-B2 Precursor organosilicon polymer of 1,2-Bis(dimethylethoxysilyl)ethane, 1,4-bis(dimethylethoxysilyl)benzene, tetraethoxysilane, methyltriethoxysilane, phenyltriethoxysilane; dielectric (DE) films having etching/chemical/moisture resistance; adhesion; low DE constant; minimal wiring delay; high speed FUJITSU LIMITED (JP) 2010-02-09 US disclosed
US-20070026689-A1 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2007-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SLTM, SKP2, BCAT2 MAPK1 1333/4885ALDH1A1 2132/4885ALOX15 4465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.