SCHEMBL7034653

SCHEMBL7034653

CC1=C(O[Si](C)(C)NC(C)(C)C)c2ccccc2C1

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.32
CHRM2 P08172 1/20 0.30
CHRM4 P08173 1/20 0.30
CHRM5 P08912 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30
MAOB P27338 1/20 0.30
BCHE P06276 1/20 0.30
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28825096 0.81 MAOA (0.33) MAOAMAOBBCHECES1
SCHEMBL817028 0.80 MAOA (0.38) MAOAMAOBBCHECES1
SCHEMBL7034170 0.72
SCHEMBL4034579 0.71 HTR2A (0.32) MAOA
SCHEMBL7034657 0.69 PTGS2 (0.36) MAOAMAOB
SCHEMBL7031079 0.68 PTGS2 (0.35) MAOAMAOB
SCHEMBL13797871 0.65
SCHEMBL817343 0.65 CES1 (0.41) MAOACHRM2CHRM4CHRM5CHRM1
SCHEMBL14884278 0.64 MAOA (0.43) MAOABCHECES1
SCHEMBL6909593 0.64 MAOA (0.31) MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6646071-B1 Catalysts for high temperature solution polymerization THE DOW CHEMICAL COMPANY 2003-11-11 US disclosed
EP-1178996-B1 METAL COMPLEXES CONTAINING BRIDGING HETEROATOM FOR OLEFIN-POLYMERIZATION-PROCESS DOW GLOBAL TECHNOLOGIES INC (US) 2003-03-05 EP disclosed