Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2793746 | 0.86 | ADORA2B (0.54) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL12413533 | 0.81 | ADORA2B (0.63) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL8750704 | 0.79 | ADORA2B (0.50) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL150602 | 0.79 | ADORA2B (0.59) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL897035 | 0.75 | ADORA2B (0.55) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL2917584 | 0.75 | ADORA2B (0.55) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL10535015 | 0.74 | ADORA2A (0.57) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL6952184 | 0.74 | SLC2A1 (0.41) | ADORA2BADORA3MAPK1LMNASMN1; SMN2 | |
| SCHEMBL481336 | 0.73 | FYN (0.50) | FYNMAPK1USP1METCYP3A4 | |
| SCHEMBL481335 | 0.73 | FYN (0.50) | FYNMAPK1USP1METCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444233-A2 | A 2B? ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003042214-A2 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2003-05-22 | — | — | WO | disclosed |