Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037199 | 1.00 | REN (0.44) | RENCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL7294934 | 0.88 | CYP3A4 (0.43) | RENCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL15619033 | 0.86 | CYP3A4 (0.44) | RENCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL15619034 | 0.86 | CYP3A4 (0.44) | RENCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL9770958 | 0.80 | REN (0.43) | RENCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL6622988 | 0.80 | POLB (0.46) | CTSLCTSBCTSSCTSKSYK | |
| SCHEMBL7331165 | 0.80 | POLB (0.46) | CTSLCTSBCTSSCTSKSYK | |
| SCHEMBL27353143 | 0.78 | REN (0.44) | RENCTSLCTSBCTSSCTSK | |
| SCHEMBL13333366 | 0.78 | CACNA1B (0.43) | RENCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL7045270 | 0.78 | CACNA1B (0.43) | RENCYP3A4CYP2C9CYP2C19CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998454-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2003-03-26 | — | — | EP | disclosed |
| US-6358987-B1 | FOR THERAPY AND PROPHYLAXIS OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL EPIDERMAL OR GASTRIC ULCERATION, AND TUMOUR METASTASIS, INVASION AND GROWTH | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2002-03-19 | — | — | US | disclosed |
| US-6271262-B1 | AMIDESULFONAMIDE COMPOUNDS AS ENZYME INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2001-08-07 | — | — | US | disclosed |