Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CFTR | P13569 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107622 | 0.85 | ALOX5 (0.55) | PTGDR2PTGS1PTGS2HTR5A | |
| SCHEMBL7040453 | 0.85 | PTGDR2 (0.50) | PTGDR2DRD3DRD2DRD1DRD5 | |
| SCHEMBL6038325 | 0.81 | HTR6 (0.66) | PTGDR2PTGS1HTR6HPGD | |
| SCHEMBL3073539 | 0.78 | PTGDR2 (1.00) | PTGDR2AKR1B10AKR1B1 | |
| SCHEMBL11845690 | 0.76 | HTR6 (0.79) | PTGDR2PTGS1PTGS2HTR6MEN1 | |
| SCHEMBL7042654 | 0.76 | BAZ2B (0.65) | DRD3DRD2DRD1DRD5CFTR | |
| SCHEMBL6336082 | 0.75 | CYP2C9 (0.58) | PTGDR2HTR5A | |
| SCHEMBL21162489 | 0.75 | CFTR (0.59) | PTGDR2DRD3DRD2DRD1DRD5 | |
| SCHEMBL21588260 | 0.75 | CFTR (0.50) | PTGDR2DRD3DRD2DRD1DRD5 | |
| SCHEMBL31117556 | 0.74 | PTGDR2 (0.62) | PTGDR2HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030216378-A1 | Azepino[4,5-b]pyrano[3,2-e]indoles | PHARMACIA & UPJOHN CO. | 2003-11-20 | — | — | US | disclosed |
| EP-1296988-A1 | AZEPINO 4,5-B]PYRANO 3,2-E]INDOLES | PHARMACIA & UPJOHN COMPANY (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020022616-A1 | Azepino[4,5-b]pyrano[3,2-e]indoles | PHARMACIA & UPJOHN COMPANY | 2002-02-21 | — | — | US | disclosed |
| WO-2002004457-A1 | AZEPINO[4,5-B]PYRANO[3,2-E]INDOLES | PHARMACIA & UPJOHN COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216378-A1 | Azepino[4,5-b]pyrano[3,2-e]indoles | NPY5R, HTR5A, IDO1 | PTGDR2 975/4885DRD3 181/4885DRD2 369/4885 |
| US-20020022616-A1 | Azepino[4,5-b]pyrano[3,2-e]indoles | NPY5R, HTR3C, HTR5A | PTGDR2 956/4885DRD3 88/4885DRD2 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.