Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815558 | 0.84 | TRPM8 (0.45) | SMN1; SMN2KDM4E | |
| SCHEMBL10191826 | 0.82 | ALDH1A1 (0.42) | ALDH1A1NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL12790160 | 0.81 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL14829898 | 0.81 | GPR142 (0.44) | ALDH1A1NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL12788371 | 0.78 | NPC1 (0.46) | ALDH1A1NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL2819462 | 0.78 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL14814420 | 0.77 | ILK (0.36) | CDC7DBF4 | |
| SCHEMBL14826117 | 0.76 | IDO1 (0.36) | — | |
| SCHEMBL2199263 | 0.75 | NPC1 (0.44) | ALDH1A1NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL20558976 | 0.75 | NPC1 (0.44) | ALDH1A1NPC1RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676409-B1 | Erythromycin derivatives, their process for preparation and their application as medicaments | AVENTIS PHARMA SA (FR) | 2003-03-19 | — | — | EP | disclosed |
| WO-1995027720-A1 | NOVEL ERYTHROMYCIN DERIVATIVES, METHOD FOR PREPARING SAME AND USE THEREOF AS DRUGS | ROUSSEL UCLAF (FR) | 1995-10-19 | — | — | WO | disclosed |
| EP-0676409-A1 | Erythromycin derivatives, their process for preparation and their application as medicaments | ROUSSEL UCLAF (FR) | 1995-10-11 | — | — | EP | disclosed |