Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040630 | 0.82 | F2 (0.54) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7040833 | 0.81 | NPC1 (0.58) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7038489 | 0.81 | ACHE (0.59) | KMT2AALDH1A1NPSR1L3MBTL1ACHE | |
| SCHEMBL28196332 | 0.80 | ACHE (0.49) | LMNAKCNQ2ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL11001026 | 0.79 | ALDH1A1 (0.52) | LMNAKCNQ2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL11312500 | 0.74 | LDHA (0.56) | LMNAMEN1KMT2AMAPTROCK2 | |
| SCHEMBL5743088 | 0.74 | CA12 (0.52) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7040224 | 0.74 | ACHE (0.48) | KCNQ2ALDH1A1ACHE | |
| SCHEMBL22593372 | 0.74 | LMNA (0.53) | LMNAMEN1KMT2AMAPTROCK2 | |
| Hydrochloric Acid SCHEMBL5743084 | 0.73 | CA12 (0.51) | LMNAMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659737-B1 | Catecholamine surrogates useful as beta 3 agonists | BRISTOL MYERS SQUIBB CO (US) | 2003-03-26 | — | — | EP | disclosed |
| US-5776983-A | ANTIDIABETIC AGENTS, OBESITY, GASTROINTESTINAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0659737-A2 | Catecholamine surrogates useful as B3 agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-28 | — | — | EP | disclosed |