Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664028 | 0.92 | LMNA (0.58) | MMP3KDM4ESMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7036402 | 0.91 | HDAC2 (0.63) | MMP3KDM4ESMN1; SMN2HTTALDH1A1 | |
| SCHEMBL30179531 | 0.90 | HDAC1 (0.66) | KDM4ESMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL620996 | 0.86 | KDM4E (0.57) | KDM4ESMN1; SMN2HTTALDH1A1TP53 | |
| SCHEMBL7041403 | 0.84 | L3MBTL1 (0.64) | KDM4ESMN1; SMN2HTTALDH1A1MAPK1 | |
| SCHEMBL4907668 | 0.82 | KDM4E (0.59) | KDM4ESMN1; SMN2HTTALDH1A1TP53 | |
| SCHEMBL28439445 | 0.79 | FFAR4 (0.67) | KDM4ESMN1; SMN2HTTALDH1A1TP53 | |
| SCHEMBL156467 | 0.78 | KDM4E (0.58) | KDM4ESMN1; SMN2HTTALDH1A1TP53 | |
| SCHEMBL8660737 | 0.78 | KDM4E (0.62) | KDM4ESMN1; SMN2HTTALDH1A1TP53 | |
| SCHEMBL7044763 | 0.78 | MMP3 (1.00) | MMP3HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292601-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2001092274-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2001-12-06 | — | — | WO | claimed |