SCHEMBL7042014

SCHEMBL7042014

COC(=O)Cc1ccc(O)c(CC(C)C)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.63
GABRB2 P47870 1/20 0.63
ALDH1A1 P00352 3/20 0.59
GAA P10253 2/20 0.59
GFER P55789 1/20 0.59
HSP90AB1 P08238 1/20 0.47
SLC7A5 Q01650 1/20 0.46
CYP4F2 P78329 1/20 0.45
CYP4A11 Q02928 1/20 0.45
TLR7 Q9NYK1 2/20 0.44
EGFR P00533 2/20 0.44
LMNA P02545 1/20 0.42
TSHR P16473 2/20 0.42
NFKB1 P19838 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
MAPT P10636 2/20 0.42
HPGD P15428 1/20 0.42
YWHAG P61981 1/20 0.41
ERCC1 P07992 1/20 0.41
ERCC4 Q92889 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8145260 0.85 ALDH1A1 (0.68) ALDH1A1GAAGFERHSP90AB1SLC7A5
SCHEMBL11452699 0.83 GABRA1 (0.69) GABRA1GABRB2ALDH1A1GAASLC7A5
SCHEMBL22273409 0.81 ALDH1A1 (0.67) ALDH1A1GAAGFERHSP90AB1SLC7A5
SCHEMBL3586640 0.80 ALDH1A1 (0.60) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL30523630 0.79 ALDH1A1 (0.59) ALDH1A1GAAGFERHSP90AB1SLC7A5
SCHEMBL7046438 0.79 ALDH1A1 (0.59) ALDH1A1GAAGFERHSP90AB1SLC7A5
SCHEMBL4014182 0.79 CYP4F2 (0.59) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL29446278 0.79 GAA (0.72) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL3668882 0.79 GAA (0.72) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL318750 0.78 GABRA1 (1.00) GABRA1GABRB2ALDH1A1HSP90AB1SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882029-B1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS MERCK & CO INC (US) 2003-04-02 EP disclosed
US-6090836-A DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION MERCK & CO., INC. (US) 2000-07-18 US disclosed
EP-0882029-A1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS Merck & Co., Inc. (US) 1998-12-09 EP disclosed
WO-1997028137-A1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS MERCK & CO., INC. (US) 1997-08-07 WO disclosed