Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036855 | 0.96 | HTR3A (0.40) | HTR3AHTR2CJAK2JAK1TYK2 | |
| SCHEMBL7042964 | 0.92 | HTR3A (0.42) | HTR3AHTR2CSOS1PIM1KCNH2 | |
| SCHEMBL7041533 | 0.89 | HTR3A (0.40) | HTR3A | |
| SCHEMBL7041296 | 0.89 | HTR3A (0.40) | HTR3AHTR2CSOS1 | |
| SCHEMBL7045272 | 0.88 | FLT3 (0.44) | HTR3ASOS1PIM1KCNH2 | |
| SCHEMBL7044695 | 0.88 | HTR3A (0.40) | HTR3AHTR2CSOS1PIM1 | |
| SCHEMBL7039363 | 0.88 | HTR3A (0.40) | HTR3AHTR2CSOS1KCNH2 | |
| SCHEMBL7046613 | 0.88 | HTR3A (0.40) | HTR3A | |
| SCHEMBL7046777 | 0.86 | HTR3A (0.39) | HTR3A | |
| SCHEMBL7043722 | 0.85 | MEN1 (0.37) | HTR3ASOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |