SCHEMBL7042970

SCHEMBL7042970

COC(=O)c1[c]n(C)nc1Cl

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.34
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
NOTUM Q6P988 1/20 0.31
KDM4E B2RXH2 3/20 0.31
HPGD P15428 2/20 0.31
GLA P06280 1/20 0.31
F2 P00734 1/20 0.31
ATR Q13535 1/20 0.31
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697963 0.74 NPC1 (0.43) NPSR1NPC1NOTUMKDM4EHPGD
SCHEMBL8371895 0.64 L3MBTL1 (0.45) NPSR1KMT2AMEN1NPC1RAB9A
SCHEMBL27351594 0.63 ADCY10 (0.43) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL25244879 0.62 KDM4E (0.37) NPSR1KMT2AMEN1NPC1RAB9A
SCHEMBL11179510 0.62 NPSR1 (0.37) NPSR1NOTUMKDM4EF2ALDH1A1
SCHEMBL1930473 0.62 NPSR1 (0.46) NPSR1KMT2ANPC1RAB9AKDM4E
SCHEMBL985062 0.60 KMT2A (0.59) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL31667226 0.60 ALDH1A1 (0.40) NPSR1KMT2AMEN1NPC1RAB9A
SCHEMBL5443795 0.60 MAPK1 (0.38) NPSR1KMT2AMEN1NPC1RAB9A
SCHEMBL7040266 0.60 NPSR1 (0.35) NPSR1KMT2AKDM4EGLAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6150301-A Chemical abscission of fruits at low application rates WILCOX MERRILL (US) 2000-11-21 US claimed
US-5886176-A Process for preparing sulphonylurea salts BAYER AKTIENGESELLSCHAFT (DE) 1999-03-23 US claimed
WO-1997040681-A1 CHEMICAL ABSCISSION OF FRUITS AT LOW APPLICATION RATES WILCOX MERRILL (US) 1997-11-06 WO claimed
EP-0559044-A1 Process for the preparation of sulfonylurea salts BAYER AG (DE) 1993-09-08 EP claimed
CN-1279818-C Herbicidal synergistic composition, and method of controlling weeds SYNGENTA CROP PROT INC (CH) 2006-10-18 CN disclosed
CN-1541532-A Herbicidal synergistic composition, and method of controlling weeds �����ɷ� 2004-11-03 CN disclosed
US-20030212116-A1 Heterocyclic imino compounds and fungicides and insecticides for agricultural and horitcultural use NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2003-11-13 US disclosed
EP-1243580-A1 HETEROCYCLIC IMINO COMPOUNDS AND FUNGICIDES AND INSECTICIDES FOR AGRICULTURAL AND HORTICULTURAL USE Nissan Chemical Industries, Ltd. (JP) 2002-09-25 EP disclosed
CN-1088063-C Sulfamidyl (thio) carbonyl-1,2,4-triazolineone derivative and preparation method and application as weed killer BAYER AG (DE) 2002-07-24 CN disclosed
US-6150301-A Chemical abscission of fruits at low application rates WILCOX MERRILL (US) 2000-11-21 US disclosed
US-5972844-A Sulphonyl amino (thio) carbonyl-1,2,4-triazolin (thi) one derivatives and the use thereof as herbicides BAYER AKTIENGESELLSCHAFT (DE) 1999-10-26 US disclosed
US-5886176-A Process for preparing sulphonylurea salts BAYER AKTIENGESELLSCHAFT (DE) 1999-03-23 US disclosed
CN-1169723-A Sulfamidyl (thio) carbonyl-1,2,4-triazolineone derivative and preparation method and application as weed killer BAYER AG (DE) 1998-01-07 CN disclosed
WO-1997040681-A1 CHEMICAL ABSCISSION OF FRUITS AT LOW APPLICATION RATES WILCOX MERRILL (US) 1997-11-06 WO disclosed
EP-0768034-A1 Synergistic herbicidal composition and method for weed control Novartis AG (CH) 1997-04-16 EP disclosed
WO-1996022982-A1 SULPHONYL AMINO(THIO)CARBONYL-1,2,4-TRIAZOLIN(THI)ONE DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1996-08-01 WO disclosed
WO-1996022284-A1 METHOD OF PREPARING SULFONYL UREAS BAYER AKTIENGESELLSCHAFT (DE) 1996-07-25 WO disclosed
EP-0559044-A1 Process for the preparation of sulfonylurea salts BAYER AG (DE) 1993-09-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030212116-A1 Heterocyclic imino compounds and fungicides and insecticides for agricultural and horitcultural use DDT, CBR3, CYP1B1 NPSR1 4301/4885KMT2A 814/4885MEN1 762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.