Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 6/20 | 0.74 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2679907 | 0.85 | MMP3 (1.00) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL7046473 | 0.80 | MMP3 (0.89) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL7043273 | 0.73 | MMP3 (0.77) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL7047645 | 0.71 | ALDH1A1 (0.44) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL4001097 | 0.70 | MMP3 (0.82) | MMP3CTSBCTSSCTSK | |
| SCHEMBL4009763 | 0.70 | MMP3 (0.82) | MMP3CTSBCTSSCTSK | |
| SCHEMBL2680161 | 0.69 | MMP3 (0.67) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL7045342 | 0.69 | HDAC1 (0.51) | MMP3LTA4HLMNAHDAC1HDAC2 | |
| SCHEMBL30504282 | 0.68 | MMP3 (0.79) | MMP3FFAR1 | |
| SCHEMBL4665401 | 0.68 | MMP3 (0.56) | MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-B1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | disclosed |
| US-5665777-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1997-09-09 | — | — | US | disclosed |