Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 12/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.46 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL27866701 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL7768957 | 0.90 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL11065185 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL31070222 | 0.89 | — | — | |
| D-Aspartate SCHEMBL31235712 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL11065189 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL3231 | 0.89 | — | — | |
| Aspartic Acid SCHEMBL996424 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL1526976 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| D-Aspartate SCHEMBL145539 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113195003-B | Drug delivery system using solution | 国立大学法人京都大学 | 2024-12-31 | — | — | CN | claimed |
| US-20220023207-A1 | DRUG DELIVERY SYSTEM USING SOLUTION | KYOTO UNIVERSITY (JP) | 2022-01-27 | — | — | US | claimed |
| EP-3888693-A1 | DRUG DELIVERY SYSTEM USING SOLUTION | Kyoto University (JP) | 2021-10-06 | — | — | EP | claimed |
| CN-113195003-A | Drug delivery system using solution | 国立大学法人京都大学 | 2021-07-30 | — | — | CN | claimed |
| CN-101611312-A | Method for screening essential metabolites in microbial growth | KOREA INST SCI & TECH (KR) | 2009-12-23 | — | — | CN | claimed |
| CN-113195003-B | Drug delivery system using solution | 国立大学法人京都大学 | 2024-12-31 | — | — | CN | disclosed |
| CN-118020888-A | Use of dihydroorotase for reducing purine content | 中国海洋大学 | 2024-05-14 | — | — | CN | disclosed |
| US-20230309502-A1 | ANIMAL LITTER COMPOSITIONS AND METHOD OF AMMONIA ABATEMENT | CONTROLLED RELEASE TECHNOLOGIES, INC. (US) | 2023-10-05 | — | — | US | disclosed |
| WO-2023158815-A1 | ANIMAL LITTER COMPOSITIONS AND METHOD OF AMMONIA ABATMENT | CONTROLLED RELEASE TECHNOLOGIES, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| US-20230056311-A1 | METHOD FOR IMPROVING PRODUCTION OF STREPTOMYCES POLYKETIDE COMPOUNDS | INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2023-02-23 | — | — | US | disclosed |
| US-20220023207-A1 | DRUG DELIVERY SYSTEM USING SOLUTION | KYOTO UNIVERSITY (JP) | 2022-01-27 | — | — | US | disclosed |
| EP-3888693-A1 | DRUG DELIVERY SYSTEM USING SOLUTION | Kyoto University (JP) | 2021-10-06 | — | — | EP | disclosed |
| CN-1314488-A | New polypeptide-human dihydroorotase 13 and polynucleotide for coding such polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2001-09-26 | — | — | CN | disclosed |
| CN-1314489-A | New polypeptide-human dihydroorotase 17 and polynucleotide for coding such polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2001-09-26 | — | — | CN | disclosed |
| CN-1312385-A | Human dihydroorotase 9 as one new polypeptide and polynucleotides encoding this polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2001-09-12 | — | — | CN | disclosed |
| CN-1311328-A | New polypeptide-human dihydrooratase 23 and polynucleotide for coding such polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2001-09-05 | — | — | CN | disclosed |
| CN-1301827-A | New polypeptide-dihydrooratase 9 polynucleotide coding such polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2001-07-04 | — | — | CN | disclosed |
| CN-1301825-A | New polypeptide-human dihydrooratase 10 and polynucleotide coding such polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2001-07-04 | — | — | CN | disclosed |
| US-6251625-B1 | ENZYMATIC PREPARATION OF PROTECTED DI- OR OLIGOPEPTIDES AND REMOVAL OF THE PROTECTIVE GROUP USED BY SPLITTING OFF | DEGUSSA AKTIENGESELLSCHAFT (DE) | 2001-06-26 | — | — | US | disclosed |
| EP-0029000-A1 | Mixed salts of an alkaline earth metal and of dimethylamino ethanol of N-acyl-glutamic acids and N-acyl-aspartic acids | INTERCO S.A. (CH) | 1981-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220023207-A1 | DRUG DELIVERY SYSTEM USING SOLUTION | PDIA6, PDIA5, DUS2 | GRIK1 4841/4885GRIK2 4862/4885GRM1 4629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.