Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.63 |
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11501912 | 0.91 | MAOB (0.67) | KDM4EALDH1A1HPGDMAPTTP53 | |
| SCHEMBL11502029 | 0.90 | MAOB (0.69) | KDM4EALDH1A1HPGDMAPTTP53 | |
| SCHEMBL7044951 | 0.81 | XDH (0.56) | KDM4EALDH1A1MAOBMAOATDP1 | |
| SCHEMBL7044938 | 0.79 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL7040569 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1HPGDMAPTTP53 | |
| SCHEMBL7042817 | 0.78 | SIGMAR1 (0.59) | — | |
| SCHEMBL11502207 | 0.78 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDMAPTTP53 | |
| SCHEMBL2465940 | 0.76 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDMAPTTP53 | |
| Giparmen SCHEMBL2109323 | 0.75 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDMAPTTP53 | |
| SCHEMBL2465863 | 0.74 | MAOB (0.53) | KDM4EALDH1A1POLBL3MBTL1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608089-B2 | Having antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy of neoplasms, for use in manufacture of medicament for menopausal disorders and osteoporosis | INDENA S.P.A. (IT) | 2003-08-19 | — | — | US | claimed |
| EP-1212312-B1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA SPA (IT) | 2003-04-02 | — | — | EP | claimed |
| CN-1371371-A | Novel derivatives of flavones, xanthones and coumarins | INDENA SPA (IT) | 2002-09-25 | — | — | CN | claimed |
| EP-1212312-B1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA SPA (IT) | 2003-04-02 | — | — | EP | disclosed |
| EP-1212312-A1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA S.p.A. (IT) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001017985-A1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA S.P.A. (IT) | 2001-03-15 | — | — | WO | disclosed |
| US-4151291-A | ANALGESICS | UNICLER (FR) | 1979-04-24 | — | — | US | disclosed |