Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465863 | 0.94 | MAOB (0.53) | XDHNPC1RAB9AATMKDM4E | |
| SCHEMBL7044938 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1TDP1ACHEBCHE | |
| SCHEMBL7042817 | 0.82 | SIGMAR1 (0.59) | ACHEBCHE | |
| SCHEMBL2464196 | 0.82 | MAOA (0.47) | NPC1RAB9AATMKDM4EALDH1A1 | |
| SCHEMBL7045130 | 0.81 | ALDH1A1 (0.53) | NPC1RAB9AKDM4EALDH1A1TDP1 | |
| SCHEMBL7044392 | 0.81 | KDM4E (0.63) | KDM4EALDH1A1TDP1MAOAMAOB | |
| SCHEMBL7040569 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1TDP1ACHEBCHE | |
| SCHEMBL2464301 | 0.75 | MAPT (0.61) | XDHNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL11501912 | 0.72 | MAOB (0.67) | NPC1RAB9AKDM4EALDH1A1TDP1 | |
| SCHEMBL6519242 | 0.71 | MAOA (0.70) | XDHNPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212312-B1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA SPA (IT) | 2003-04-02 | — | — | EP | claimed |
| US-6608089-B2 | Having antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy of neoplasms, for use in manufacture of medicament for menopausal disorders and osteoporosis | INDENA S.P.A. (IT) | 2003-08-19 | — | — | US | disclosed |
| EP-1212312-B1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA SPA (IT) | 2003-04-02 | — | — | EP | disclosed |