Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688831 | 0.86 | SMN1; SMN2 (0.57) | HPGDOPRK1SMN1; SMN2CYP2C9CYP2D6 | |
| SCHEMBL4415354 | 0.86 | SMN1; SMN2 (0.57) | HPGDOPRK1SMN1; SMN2CYP2C9CYP2D6 | |
| SCHEMBL4422153 | 0.84 | HPGD (0.74) | HPGDOPRK1PDE4DMEN1KMT2A | |
| SCHEMBL11652182 | 0.83 | HPGD (0.46) | HPGDOPRK1PDE4DSMN1; SMN2CYP2C9 | |
| SCHEMBL12769741 | 0.79 | ALDH1A1 (0.38) | HPGDSMN1; SMN2CYP2C9CYP2D6MAPT | |
| SCHEMBL11559256 | 0.78 | OPRK1 (0.70) | HPGDOPRK1PDE4DCYP2C9MEN1 | |
| SCHEMBL30087538 | 0.78 | OPRK1 (0.70) | HPGDOPRK1PDE4DCYP2C9MEN1 | |
| SCHEMBL11554112 | 0.78 | SMN1; SMN2 (0.50) | OPRK1PDE4DSMN1; SMN2CYP2C9CYP2D6 | |
| SCHEMBL8616731 | 0.75 | CCKBR (0.51) | HPGDOPRK1PDE4DMEN1KMT2A | |
| SCHEMBL8898463 | 0.75 | CCKBR (0.50) | HPGDOPRK1PDE4DMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842156-B1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0842156-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0842156-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5700797-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO, INC. (US) | 1997-12-23 | — | — | US | disclosed |
| WO-1996040654-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |