Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11617258 | 0.91 | TDP1 (0.55) | GSK3BPTPN1TDP1NPC1RAB9A | |
| SCHEMBL10661203 | 0.84 | ALDH1A1 (0.50) | GSK3BPTPN1TDP1NPC1RAB9A | |
| SCHEMBL524255 | 0.84 | CES2 (0.50) | LMNAMAPK1CYP3A4CES1ALDH1A1 | |
| SCHEMBL8889723 | 0.83 | CES2 (0.53) | TDP1L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL9695930 | 0.83 | CES2 (0.53) | TDP1L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL10498007 | 0.83 | CES2 (0.53) | TDP1L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL9414538 | 0.83 | CES2 (0.53) | TDP1L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL9280452 | 0.83 | CES2 (0.53) | TDP1L3MBTL1MAPTLMNAMAPK1 | |
| Pentane SCHEMBL28744442 | 0.83 | CES2 (0.49) | LMNAMAPK1CYP3A4CES1ALDH1A1 | |
| SCHEMBL10497507 | 0.83 | CES2 (0.53) | TDP1L3MBTL1MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130232-A1 | Amidine derivatives, the preparation and use thereof as medicaments with LTB4 antagonistic effect | BOEHRINGER INGELHEIM KG (DE) | 2003-07-10 | — | — | US | disclosed |
| US-6489365-B1 | LTB4-ANTAGONISTIC COMPOUNDS FOR TREATMENT OF INFLAMMATION, ALLERGY OR GASTROPATHY INDUCED BY NON-STEROIDAL ANTIINFLAMMATORY AGENTS IN A WARM-BLOODED ANIMALS | BOEHRINGER INGELHEIM KG (DE) | 2002-12-03 | — | — | US | disclosed |
| EP-0902013-B1 | Novel amidine derivatives, their preparation and their use as medicaments with LTB-4 antagonistic effect | BOEHRINGER INGELHEIM INT (DE) | 2001-12-12 | — | — | EP | disclosed |
| US-6037377-A | ANTIINFLAMMATORY AGENTS AND ANTIALLERGENS | BOEHRINGER INGELHEIM KG (DE) | 2000-03-14 | — | — | US | disclosed |
| EP-0625138-B1 | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS WITH LTB4 ANTAGONISTIC EFFECT | BOEHRINGER INGELHEIM INT (DE) | 1999-06-02 | — | — | EP | disclosed |
| EP-0902013-A1 | Novel amidine derivatives, their preparation and their use as medicaments with LTB-4 antagonistic effect | BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) | 1999-03-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130232-A1 | Amidine derivatives, the preparation and use thereof as medicaments with LTB4 antagonistic effect | LTB4R2, LTB4R, LTA4H | GSK3B 4115/4885PTPN1 2020/4885TDP1 3785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.