Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 17/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 15/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 13/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.47 |
| ▸ | CFB | P00751 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9788291 | 0.86 | TAAR1 (0.45) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL7046036 | 0.85 | TAAR1 (0.57) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL9788328 | 0.84 | ADRA2A (0.45) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL7048730 | 0.81 | TAAR1 (0.60) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL7044968 | 0.80 | NISCH (0.46) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL7047648 | 0.78 | TAAR1 (0.56) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL9558789 | 0.78 | CFB (0.48) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL9788321 | 0.76 | TAAR1 (0.48) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL9788340 | 0.76 | CFB (0.50) | TAAR1ADRA2AADRA2CADRA2BADRA1A | |
| SCHEMBL9788317 | 0.76 | CFB (0.44) | TAAR1ADRA2AADRA2CADRA2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724439-B1 | USE OF 2-(2ALKYLPHENYLAMINO)OXAZOLINES AND -THIAZOLINES FOR THE MANUFACTURE OF A MEDICAMENT WITH ALPHA 2 ADRENERGIC EFFECT | ALLERGAN SALES INC (US) | 2003-04-09 | — | — | EP | disclosed |
| US-5708015-A | SENSITIVE ALPHA 2 ADRENERGIC RECEPTORS | ALLERGAN (US) | 1998-01-13 | — | — | US | disclosed |
| US-5580892-A | ANTIDIARRHETIC, ANTISPASTIC, ANTIEPILEPTIC AGENTS; DIURETICS | ALLERGAN | 1996-12-03 | — | — | US | disclosed |
| EP-0724439-A1 | USE OF 2-(2-ALKYLPHENYLAMINO)-OXAZOLINES, -THIAZOLINES AND -IMIDAZOLINES AS ALPHA 2 ADRENERGIC AGENTS | Allergan (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011021-A1 | USE OF 2-(2-ALKYLPHENYLAMINO)-OXAZOLINES, -THIAZOLINES AND -IMIDAZOLINES AS ALPHA 2 ADRENERGIC AGENTS | ALLERGAN (US) | 1995-04-27 | — | — | WO | disclosed |
| US-5252595-A | Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines | ALLERGAN, INC. (US) | 1993-10-12 | — | — | US | disclosed |
| US-5151440-A | Treatment of glaucoma | ALLERGAN, INC. (US) | 1992-09-29 | — | — | US | disclosed |