Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23120251 | 0.81 | KDM4E (0.38) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL457599 | 0.80 | TYMS (0.37) | TYMSMAPTLMNANPC1RAB9A | |
| SCHEMBL7049654 | 0.77 | HPGD (0.42) | MAPTLMNARAB9ASMN1; SMN2TDP1 | |
| SCHEMBL29563614 | 0.76 | ALDH1A1 (0.41) | MAPTLMNANPC1SMN1; SMN2TDP1 | |
| SCHEMBL3258162 | 0.76 | ALDH1A1 (0.41) | MAPTLMNANPC1SMN1; SMN2TDP1 | |
| SCHEMBL29181691 | 0.72 | ALDH1A1 (0.49) | LMNATDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL15994595 | 0.71 | TDP1 (0.39) | TYMSLMNARAB9ATDP1L3MBTL1 | |
| SCHEMBL28581997 | 0.70 | KDM4E (0.38) | SMN1; SMN2KDM4EGPR3 | |
| SCHEMBL31684807 | 0.69 | KDM4E (0.59) | TYMSMAPTLMNANPC1RAB9A | |
| SCHEMBL159416 | 0.69 | KDM4E (0.59) | TYMSMAPTLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800634-B2 | ANTICANCER AGENTS | ICONIX PHARMACEUTICALS INC. | 2004-10-05 | — | — | US | disclosed |
| US-20030171390-A1 | Modulators of Rho C activity | ENTELOS HOLDING CORP. | 2003-09-11 | — | — | US | disclosed |
| WO-2003043582-A2 | MODULATORS OF RHO C ACTIVITY | ICONIX PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171390-A1 | Modulators of Rho C activity | RHOC, ARHGEF1, ROCK1 | TYMS 4643/4885MAPT 4272/4885LMNA 1790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.